Matches in SemOpenAlex for { <https://semopenalex.org/work/W2526890> ?p ?o ?g. }
- W2526890 endingPage "204" @default.
- W2526890 startingPage "189" @default.
- W2526890 abstract "Intratumoral hypoxia is prevalent in many solid tumors and is a marker of poor clinical prognosis in prostate cancer. The presence of hypoxia is associated with increased chromosomal instability, gene amplification, downregulation of DNA damage repair pathways, and altered sensitivity to agents that damage DNA. These genomic changes could also lead to oncogene activation or tumor suppressor gene inactivation during prostate cancer progression. We review here the concept of repair-deficient hypoxic tumor cells that can adapt to low oxygen levels and acquire an aggressive “unstable mutator” phenotype. We speculate that hypoxia-induced genomic instability may also be a consequence of aberrant mitotic function in hypoxic cells, which leads to increased chromosomal instability and aneuploidy. Because both hypoxia and aneuploidy are prognostic factors in prostate cancer, a greater understanding of these biological states in prostate cancer may lead to novel prognostic and predictive tests and drive new therapeutic strategies in the context of personalized cancer medicine." @default.
- W2526890 created "2016-06-24" @default.
- W2526890 creator A5020744487 @default.
- W2526890 creator A5064491747 @default.
- W2526890 creator A5089674017 @default.
- W2526890 date "2013-10-23" @default.
- W2526890 modified "2023-10-10" @default.
- W2526890 title "Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer" @default.
- W2526890 cites W1779185681 @default.
- W2526890 cites W1963941229 @default.
- W2526890 cites W1965560988 @default.
- W2526890 cites W1969637146 @default.
- W2526890 cites W1973769650 @default.
- W2526890 cites W1979933406 @default.
- W2526890 cites W1987546235 @default.
- W2526890 cites W1993475190 @default.
- W2526890 cites W1996830477 @default.
- W2526890 cites W1999002383 @default.
- W2526890 cites W2007269128 @default.
- W2526890 cites W2009754997 @default.
- W2526890 cites W2012276721 @default.
- W2526890 cites W2013826273 @default.
- W2526890 cites W2017046792 @default.
- W2526890 cites W2017157952 @default.
- W2526890 cites W2017289276 @default.
- W2526890 cites W2024903578 @default.
- W2526890 cites W2025047585 @default.
- W2526890 cites W2025829112 @default.
- W2526890 cites W2028285902 @default.
- W2526890 cites W2032248063 @default.
- W2526890 cites W2033771434 @default.
- W2526890 cites W2036073175 @default.
- W2526890 cites W2041273888 @default.
- W2526890 cites W2041365708 @default.
- W2526890 cites W2042879563 @default.
- W2526890 cites W2043871972 @default.
- W2526890 cites W2044367190 @default.
- W2526890 cites W2047242030 @default.
- W2526890 cites W2047687247 @default.
- W2526890 cites W2050350916 @default.
- W2526890 cites W2061598804 @default.
- W2526890 cites W2064242375 @default.
- W2526890 cites W2066362104 @default.
- W2526890 cites W2077398494 @default.
- W2526890 cites W2077640472 @default.
- W2526890 cites W2077892030 @default.
- W2526890 cites W2084087078 @default.
- W2526890 cites W2085947150 @default.
- W2526890 cites W2087377825 @default.
- W2526890 cites W2093149056 @default.
- W2526890 cites W2093531978 @default.
- W2526890 cites W2094377580 @default.
- W2526890 cites W2094847734 @default.
- W2526890 cites W2096551220 @default.
- W2526890 cites W2099943387 @default.
- W2526890 cites W2100942607 @default.
- W2526890 cites W2102570250 @default.
- W2526890 cites W2105537697 @default.
- W2526890 cites W2108949570 @default.
- W2526890 cites W2113836212 @default.
- W2526890 cites W2115228718 @default.
- W2526890 cites W2118010724 @default.
- W2526890 cites W2124470568 @default.
- W2526890 cites W2126669622 @default.
- W2526890 cites W2128488659 @default.
- W2526890 cites W2129953000 @default.
- W2526890 cites W2133386306 @default.
- W2526890 cites W2135452328 @default.
- W2526890 cites W2143925527 @default.
- W2526890 cites W2150195554 @default.
- W2526890 cites W2151211931 @default.
- W2526890 cites W2160543963 @default.
- W2526890 cites W2161340431 @default.
- W2526890 cites W2162236189 @default.
- W2526890 cites W2165241843 @default.
- W2526890 cites W2166053174 @default.
- W2526890 cites W2171435189 @default.
- W2526890 cites W2171972386 @default.
- W2526890 cites W2323738288 @default.
- W2526890 cites W2403163836 @default.
- W2526890 cites W2409921527 @default.
- W2526890 cites W2418223627 @default.
- W2526890 cites W4211190352 @default.
- W2526890 cites W4232701668 @default.
- W2526890 doi "https://doi.org/10.1007/978-1-4614-5915-6_9" @default.
- W2526890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24272360" @default.
- W2526890 hasPublicationYear "2013" @default.
- W2526890 type Work @default.
- W2526890 sameAs 2526890 @default.
- W2526890 citedByCount "29" @default.
- W2526890 countsByYear W25268902014 @default.
- W2526890 countsByYear W25268902015 @default.
- W2526890 countsByYear W25268902016 @default.
- W2526890 countsByYear W25268902017 @default.
- W2526890 countsByYear W25268902018 @default.
- W2526890 countsByYear W25268902019 @default.
- W2526890 countsByYear W25268902020 @default.
- W2526890 countsByYear W25268902021 @default.