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- W2526902938 abstract "【目的】複数のI群抗不整脈薬治療抵抗性発作性心房細動 (Paf) に対するアミオダロン (Am) の長期予防効果 (観察期間38.4±12.0カ月) を他剤I群抗不整脈薬と比較した.【方法・結果】第1 (IaあるいはIb) ならびに第2 (Icあるいはベプリジル) 選択薬後の再発性Paf55例を対象に第3選択薬をAm (A群, n=21) と他剤1群抗不整脈薬 (B群, n=34) に振り分けた, 1カ月, 3カ月, 6カ月, 9カ月, 12カ月後の経時的非再発率は, A群90.5%, 71.4%, 66.7%, 61.9%, 42.8%, B群82.4%, 64.7%, 47.1%, 26.5%, 18.6%であり, 観察期間12カ月目で有意にA群で高率で, 洞調律維持期間はA群9.0±1.7カ月, B群5.6±1.1カ月で, 有意にA群で長かった (mean±SE, p<0.05) .Paf慢性化例はA群7例 (33.3%) , B群11例 (32.4%) で有意差を認めなかったが, 慢性化までの洞調律維持期間はA群29.9±3.6カ月, B群17.6±2, 0カ月で, 有意にA群で長かった (mean±SE, p<0.05) .【結語】抗不整脈薬療法抵抗例においてAmはI群抗不整脈薬に比し長期の洞調律維持が期待される." @default.
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- W2526902938 date "2001-01-01" @default.
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- W2526902938 doi "https://doi.org/10.5105/jse.21.316" @default.
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