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• W2526975129 abstract "Adenovirus-mediated gene therapy is a promising strategy for bladder cancer treatment. However, the loss of the coxsackie and adenovirus receptor (CAR) in bladder cancer cells decreases the infection efficiency of the therapeutic adenovirus. In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter. Then, we tested the bladder cancer specificity of the UPII promotor and the expression of the HSV-TK protein. Additionally, we observed a potent cytotoxic effects of RGDAd-UPII-TK and ganciclovir (GCV) on bladder cancer as demonstrated by reduced cell survival and morphology changes in vitro. Furthermore, we confirmed that RGDAd-UPII-TK in combination with a GCV injection could significantly reduce the established T24 tumor growth and increase apoptosis in vivo. Altogether, our results indicated that the recombinant adenovirus RGDAd-UPII-TK could target bladder cancer through valid gene therapy." @default.
• W2526975129 created "2016-10-07" @default.
• W2526975129 creator A5049938387 @default.
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• W2526975129 date "2016-09-28" @default.
• W2526975129 modified "2023-09-27" @default.
• W2526975129 title "Fiber-modified adenovirus-mediated suicide gene therapy can efficiently eliminate bladder cancer cells <i>in vitro</i> and <i>in vivo</i>" @default.
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• W2526975129 doi "https://doi.org/10.18632/oncotarget.12324" @default.
• W2526975129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5342114" @default.
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• W2526975129 hasPublicationYear "2016" @default.
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