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- W2527024269 abstract "e15553 Background: To evaluate the efficacy and safety of carboplatin plus paclitaxel in patients with advanced loco regional, recurrent and metastatic endometrial cancer. Methods: Thirty two eligible patients (median age 62, range 41-72) with measurable endometrial cancer were treated with carboplatin (AUC = 6) and paclitaxel (175 mg/m3) every 4 weeks for 6 cycles or until disease progression or severe toxicity. Results: The overall response rate was 54% (16 out of 30), complete remission (CR) in 4 and partial remission (PR) in 12. The median progression free survival was 8.2 months. Six months overall survival was seen in 80%. Toxicity was generally tolerated. Conclusions: The combination of carboplatin plus paclitaxel was well tolerated in this trial. This regimen demonstrated feasible activity in advanced endometrial cancer compared to other combination therapies used before, in terms of response rate and toxicity. No significant financial relationships to disclose." @default.
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- W2527024269 date "2010-05-20" @default.
- W2527024269 modified "2023-09-25" @default.
- W2527024269 title "Carboplatin plus paclitaxel as first-line therapy for locally advanced recurrent metastatic endometrial cancer." @default.
- W2527024269 doi "https://doi.org/10.1200/jco.2010.28.15_suppl.e15553" @default.
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