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• W2527042101 abstract "<p>ABSTRACT<br />Objective: Hypertension is the most common cardiovascular disease and one of the most important public health concerns all over the world. Primary<br />or essential hypertension is the major form of arterial hypertension without any definitive cause. It results from increase vascular tone and resistance<br />which may be confined to the lower level of endothelial derived relaxing factor such as nitric oxide (NO). Hence, the objective of this study is to find<br />out whether any correlation exists between the concentrations of serum NO (nitrite) and essential hypertensive patients categorized according to the<br />Joint National Committee 7 classification.<br />Methods: We selected age- and sex-matched 24 healthy individuals as controls and 35 essential hypertensive patients as cases. Out of 35 cases, 24<br />were included in stage 1 and 11 in stage 2 of essential hypertension. We estimated serum NO levels in study groups basing on the principle of Griess<br />reaction.<br />Results: We observed reduction in mean serum NO level in cases which was statistically highly significant as compared to controls (8.14±0.33 vs.<br />13.53±0.38 µmol/L, p&lt;0.001) and also in stage 2 patients when compared with stage 1 patients (5.97±0.31 vs. 9.15±0.28 µmol/L, p&lt;0.001). In<br />hypertensive patients, serum NO showed a highly significant inverse correlation to both systolic (r=−0.89, p&lt;0.001) as well as diastolic (r=−0.64,<br />p&lt;0.001) blood pressure.<br />Conclusion: Thus, we can conclude that lower level of serum NO can be an important causative factor in the progress of essential hypertension.<br />Keywords: Essential hypertension, Endothelial-derived relaxing factor, Nitric oxide, Joint National Committee 7.</p>" @default.
• W2527042101 created "2016-10-07" @default.
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• W2527042101 date "2016-09-26" @default.
• W2527042101 modified "2023-09-28" @default.
• W2527042101 title "EVALUATION OF SERUM NITRIC OXIDE IN ESSENTIAL HYPERTENSION AND ITS CORRELATION WITH SEVERITY OF DISEASE" @default.
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• W2527042101 doi "https://doi.org/10.22159/ajpcr.2016.v9s2.13464" @default.
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