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- W2527252012 abstract "Oxidation of critical signaling protein cysteines regulated by H2O2 has been considered to involve sulfenic acid (RSOH) formation. RSOH may subsequently form either a sulfenyl amide (RSNHR′) with a neighboring amide, or a mixed disulfide (RSSR′) with another protein cysteine or glutathione. Previous studies have claimed that RSOH can be detected as an adduct (e.g., with 5,5-dimethylcyclohexane-1,3-dione; dimedone). Here, kinetic data are discussed which indicate that few proteins can form RSOH under physiological signaling conditions. We also present experimental evidence that indicates that (1) dimedone reacts rapidly with sulfenyl amides, and more rapidly than with sulfenic acids, and (2) that disulfides can react reversibly with amides to form sulfenyl amides. As some proteins are more stable as the sulfenyl amide than as a glutathionylated species, the former may account for some of the species previously identified as the “sulfenome” - the cellular complement of reversibly-oxidized thiol proteins generated via sulfenic acids." @default.
- W2527252012 created "2016-10-07" @default.
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- W2527252012 date "2017-03-01" @default.
- W2527252012 modified "2023-09-27" @default.
- W2527252012 title "Protein cysteine oxidation in redox signaling: Caveats on sulfenic acid detection and quantification" @default.
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- W2527252012 doi "https://doi.org/10.1016/j.abb.2016.09.013" @default.
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