Matches in SemOpenAlex for { <https://semopenalex.org/work/W2527424055> ?p ?o ?g. }
- W2527424055 endingPage "64" @default.
- W2527424055 startingPage "53" @default.
- W2527424055 abstract "During the past two decades, studies of xenobiotic detoxification by molecular biology in diverse organisms have identified many novel environmental adaptations, providing valuable insight into habitat, dietary preferences and general physiology. While xenobiotic detoxification has been extensively studied in eutherian mammals, metabolic data concerning detoxification in Australian marsupials are limited, particularly at the molecular level of the enzymes involved. At present Australia relies heavily on overseas data to determine the possible outcomes of xenobiotic exposure in Australian native fauna. Unlike eutherian mammals, many marsupial herbivores ingest and absorb large amounts of dietary Eucalyptus terpenes. Such quantities would be toxic, even potentially fatal, to human and many other mammalian species. Specialist Eucalyptus herbivores, such as koalas and brushtail possums, have been hypothesised to utilise highly efficient enzyme systems to metabolise terpenes to non-toxic substances that can be readily excreted in the urine. Enzymes that carry out the biotransformation of Eucalyptus terpenes have been partially identified to be the cytochromes P450 (CYP).<br. <br. The aim of this review is to provide a summary of work being undertaken over several years in our laboratories that has provided unique insights into marsupial biology. The focuses of this study are phase I and phase II metabolisms in these unique animals, the multiplicity of metabolising enzymes/pathways involved, induction/inhibition of CYPs/other enzymes by dietary Eucalyptus terpenes and to update current knowledge of xenobiotic metabolism in Australian marsupials. The important role of marsupial genome studies in identifying evolutionary relationships and functions for mammalian genes as well as in conservation, ecology and pest management of marsupial species is also briefly highlighted." @default.
- W2527424055 created "2016-10-07" @default.
- W2527424055 creator A5049704456 @default.
- W2527424055 creator A5051351126 @default.
- W2527424055 creator A5068564328 @default.
- W2527424055 creator A5069388405 @default.
- W2527424055 creator A5083488703 @default.
- W2527424055 creator A5024499431 @default.
- W2527424055 date "2008-01-01" @default.
- W2527424055 modified "2023-10-01" @default.
- W2527424055 title "Molecular Insights into Xenobiotic Disposition in Australian Marsupials" @default.
- W2527424055 cites W1509781249 @default.
- W2527424055 cites W1560504065 @default.
- W2527424055 cites W1570264510 @default.
- W2527424055 cites W1584188206 @default.
- W2527424055 cites W1588412191 @default.
- W2527424055 cites W1597685893 @default.
- W2527424055 cites W1819358448 @default.
- W2527424055 cites W1826757475 @default.
- W2527424055 cites W1923129209 @default.
- W2527424055 cites W1924031627 @default.
- W2527424055 cites W1967425934 @default.
- W2527424055 cites W1969005271 @default.
- W2527424055 cites W1969592782 @default.
- W2527424055 cites W1969712051 @default.
- W2527424055 cites W1970375490 @default.
- W2527424055 cites W1974889283 @default.
- W2527424055 cites W1975466875 @default.
- W2527424055 cites W1977055276 @default.
- W2527424055 cites W1980693252 @default.
- W2527424055 cites W1981672173 @default.
- W2527424055 cites W1982523067 @default.
- W2527424055 cites W1983628788 @default.
- W2527424055 cites W1985714764 @default.
- W2527424055 cites W1990824916 @default.
- W2527424055 cites W1993061839 @default.
- W2527424055 cites W1993561149 @default.
- W2527424055 cites W1995986160 @default.
- W2527424055 cites W1997528909 @default.
- W2527424055 cites W1999616938 @default.
- W2527424055 cites W2005198054 @default.
- W2527424055 cites W2005503186 @default.
- W2527424055 cites W2005538532 @default.
- W2527424055 cites W2007340440 @default.
- W2527424055 cites W2011174931 @default.
- W2527424055 cites W2011204400 @default.
- W2527424055 cites W2011369269 @default.
- W2527424055 cites W2011376241 @default.
- W2527424055 cites W2011829897 @default.
- W2527424055 cites W2011887673 @default.
- W2527424055 cites W2013695717 @default.
- W2527424055 cites W2016756631 @default.
- W2527424055 cites W2019925008 @default.
- W2527424055 cites W2032079030 @default.
- W2527424055 cites W2032240686 @default.
- W2527424055 cites W2035178674 @default.
- W2527424055 cites W2036712119 @default.
- W2527424055 cites W2037294498 @default.
- W2527424055 cites W2037397820 @default.
- W2527424055 cites W2037637049 @default.
- W2527424055 cites W2045653366 @default.
- W2527424055 cites W2051502288 @default.
- W2527424055 cites W2059045499 @default.
- W2527424055 cites W2059489763 @default.
- W2527424055 cites W2060180669 @default.
- W2527424055 cites W2060667909 @default.
- W2527424055 cites W2062345788 @default.
- W2527424055 cites W2063467951 @default.
- W2527424055 cites W2072436625 @default.
- W2527424055 cites W2073392355 @default.
- W2527424055 cites W2073421442 @default.
- W2527424055 cites W2077614712 @default.
- W2527424055 cites W2078529935 @default.
- W2527424055 cites W2080055549 @default.
- W2527424055 cites W2082182436 @default.
- W2527424055 cites W2088392077 @default.
- W2527424055 cites W2089312184 @default.
- W2527424055 cites W2090063888 @default.
- W2527424055 cites W2091023332 @default.
- W2527424055 cites W2094380780 @default.
- W2527424055 cites W2096408550 @default.
- W2527424055 cites W2102564327 @default.
- W2527424055 cites W2106632477 @default.
- W2527424055 cites W2109618648 @default.
- W2527424055 cites W2110363463 @default.
- W2527424055 cites W2120406379 @default.
- W2527424055 cites W2123019895 @default.
- W2527424055 cites W2123067992 @default.
- W2527424055 cites W2124463172 @default.
- W2527424055 cites W2124782035 @default.
- W2527424055 cites W2127294029 @default.
- W2527424055 cites W2132927623 @default.
- W2527424055 cites W2134483287 @default.
- W2527424055 cites W2141785980 @default.
- W2527424055 cites W2144058395 @default.
- W2527424055 cites W2145327188 @default.
- W2527424055 cites W2150140328 @default.
- W2527424055 cites W2150706449 @default.