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• W2527648889 endingPage "414" @default.
• W2527648889 startingPage "401" @default.
• W2527648889 abstract "When parts of the brain suffer from damage, certain functional deficits or impairments are the expected and typical outcome. A myriad of examples show such negative consequences, which afford the daily tasks of neurologists, neuropsychologists, and also behavioral neuroscientists working with experimental brain lesions. Compared to lesion-induced deficits, examples for functional enhancements or facilitation after brain lesions are rather rare and usually not well studied. Here, the mammalian hippocampus seems to provide an exception, since substantial evidence shows that its damage can have facilitatory behavioral effects under certain conditions. This review will address these effects and their possible mechanisms. It will show that facilitatory effects of hippocampal lesions, although mostly studied in rats, can be found in many mammalian species, that is, they are apparently not species-specific. Furthermore, they can be found with various lesion techniques, from tissue ablation, to neurotoxic damage, and from damage of hippocampal structure itself to damage of fiber systems innervating it. The major emphasis of this review, however, lies on the behavioral effects and their interpretations. Thus, facilitatory effects can be found in several learning paradigms, especially active avoidance, and some forms of Pavlovian and instrumental conditioning. These will be discussed in light of pertinent theories of hippocampal function, such as inhibition, spatial cognition, and multiple memory systems theories, which state that facilitatory effects of hippocampal lesions may reflect the loss of interference between hippocampal spatial and striatal procedural cognition. Using the example of the rat sequential reaction time task, it will also be discussed how such lesions can have direct and indirect consequences on certain behavioral readouts. A final note will advocate considering possible functional facilitation also in neurologic patients, especially those with hippocampal damage, since such a strategy might provide new avenues for therapeutic treatments." @default.
• W2527648889 created "2016-10-07" @default.
• W2527648889 creator A5039207359 @default.
• W2527648889 creator A5057186547 @default.
• W2527648889 date "2017-01-01" @default.
• W2527648889 modified "2023-10-13" @default.
• W2527648889 title "Behavioral facilitation after hippocampal lesion: A review" @default.
• W2527648889 cites W1008961576 @default.
• W2527648889 cites W105329540 @default.
• W2527648889 cites W127445890 @default.
• W2527648889 cites W1508550656 @default.
• W2527648889 cites W1541929773 @default.
• W2527648889 cites W1608105618 @default.
• W2527648889 cites W1766797326 @default.
• W2527648889 cites W1908113234 @default.
• W2527648889 cites W1921383166 @default.
• W2527648889 cites W1963634631 @default.
• W2527648889 cites W1965219739 @default.
• W2527648889 cites W1966650995 @default.
• W2527648889 cites W1966854237 @default.
• W2527648889 cites W1967189857 @default.
• W2527648889 cites W1969569106 @default.
• W2527648889 cites W1971081445 @default.
• W2527648889 cites W1973292235 @default.
• W2527648889 cites W1973529564 @default.
• W2527648889 cites W1973896341 @default.
• W2527648889 cites W1974960577 @default.
• W2527648889 cites W1978109396 @default.
• W2527648889 cites W1978575305 @default.
• W2527648889 cites W1978611927 @default.
• W2527648889 cites W1981462317 @default.
• W2527648889 cites W1982929307 @default.
• W2527648889 cites W1984214648 @default.
• W2527648889 cites W1985454926 @default.
• W2527648889 cites W1985901002 @default.
• W2527648889 cites W1989375389 @default.
• W2527648889 cites W1990203140 @default.
• W2527648889 cites W1991887315 @default.
• W2527648889 cites W1992655095 @default.
• W2527648889 cites W1995327963 @default.
• W2527648889 cites W1997428570 @default.
• W2527648889 cites W1998586635 @default.
• W2527648889 cites W2000256347 @default.
• W2527648889 cites W2003917763 @default.
• W2527648889 cites W2004305039 @default.
• W2527648889 cites W2005788545 @default.
• W2527648889 cites W2008322133 @default.
• W2527648889 cites W2009454985 @default.
• W2527648889 cites W2009664661 @default.
• W2527648889 cites W2009754984 @default.
• W2527648889 cites W2010090174 @default.
• W2527648889 cites W2010258110 @default.
• W2527648889 cites W2011379564 @default.
• W2527648889 cites W2012087299 @default.
• W2527648889 cites W2013091495 @default.
• W2527648889 cites W2017169966 @default.
• W2527648889 cites W2018312416 @default.
• W2527648889 cites W2018340639 @default.
• W2527648889 cites W2021536485 @default.
• W2527648889 cites W2024347031 @default.
• W2527648889 cites W2025801062 @default.
• W2527648889 cites W2025940948 @default.
• W2527648889 cites W2026811114 @default.
• W2527648889 cites W2027808327 @default.
• W2527648889 cites W2028758164 @default.
• W2527648889 cites W2029559867 @default.
• W2527648889 cites W2032622568 @default.
• W2527648889 cites W2032724628 @default.
• W2527648889 cites W2032747448 @default.
• W2527648889 cites W2032759049 @default.
• W2527648889 cites W2033864253 @default.
• W2527648889 cites W2034386836 @default.
• W2527648889 cites W2037372622 @default.
• W2527648889 cites W2038436325 @default.
• W2527648889 cites W2040296549 @default.
• W2527648889 cites W2041693266 @default.
• W2527648889 cites W2041737640 @default.
• W2527648889 cites W2046425041 @default.
• W2527648889 cites W2047826566 @default.
• W2527648889 cites W2051005796 @default.
• W2527648889 cites W2052161167 @default.
• W2527648889 cites W2054332285 @default.
• W2527648889 cites W2054641038 @default.
• W2527648889 cites W2055989791 @default.
• W2527648889 cites W2057861256 @default.
• W2527648889 cites W2058563518 @default.
• W2527648889 cites W2059215368 @default.
• W2527648889 cites W2059500422 @default.
• W2527648889 cites W2060089320 @default.
• W2527648889 cites W2063525265 @default.
• W2527648889 cites W2063574575 @default.
• W2527648889 cites W2063592880 @default.
• W2527648889 cites W2067142246 @default.
• W2527648889 cites W2067830356 @default.
• W2527648889 cites W2070102952 @default.
• W2527648889 cites W2070766539 @default.
• W2527648889 cites W2072011009 @default.
• W2527648889 cites W2072738402 @default.

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