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• W2527685052 abstract "To evaluate the prognostic value of baseline quality of life (QOL) on overall survival in patients receiving stereotactic radiosurgery for brain metastases. One-hundred and ninety-eight patients undergoing stereotactic radiosurgery (SRS) alone (Gamma Knife) for brain metastases were treated between 5/2007 and 11/2014. EORTC QLQ-C30 and BN-20 surveys were collected at baseline and given to patients every 3 months after treatment. The EORTC QLQ-C30 is a 30-question survey that evaluates quality-of-life along global, functional and symptom scales. The EORTC QLQ-BN20 is a 20-question survey designed specifically for patients with brain malignancies. All patients had baseline QOL and survival data available for analysis. The median number of metastases treated was 2 (range 1-14). The median treatment volume was 6.4 cm2 (range 0.1-60.9 cm2). The most common primary tumor sites were lung (66%), breast (14%), and melanoma (5%). Patients with a history of concurrent or prior whole brain RT or resection were excluded. Forty-nine percent of patients had chemotherapy either before or following SRS, within a median of 1 month (range 0-90 months). Univariate and multivariate Cox proportional hazards regression were used to identify baseline demographic, tumor, treatment, and quality-of-life predictors of overall survival. Median follow-up was 7.4 months (18 months for living patients). Median age was 62 years (range 30-89 years). Fifty-eight percent, 21%, 9%, 8%, and 5% of patients had KPS of 100, 90, 80, 70, and less than 70, respectively. Eighty percent of patients were RPA 2. Median overall survival was 10.1 months. The mean Global Health Status / Quality of Life score was 55.2, and the highest symptom scales were insomnia (46.3), fatigue (45.5), future uncertainty (41.3), and pain (33.3). On univariate analysis, younger age (P = 0.016), higher KPS (P < 0.001), lower RPA class (P = 0.001), improved physical functioning (P = 0.023), decreased nausea/vomiting (P = 0.006), and decreased diarrhea (P = 0.031) were associated with improved overall survival. The final multivariate model found lower RPA class (HR = 3.131, 95% CI = 1.717 – 5.709, P < 0.001), higher physical functioning (HR = .992, 95% CI = .985 - .999, P = .017), and decreased nausea/vomiting (HR = 1.013, 95% CI 1.005-1.022, P = 0.002) to be predictive of improved overall survival. Baseline QOL scores can be predictive of overall survival in patients with brain metastases treated with radiosurgery alone. Higher physical functioning and decreased nausea/vomiting at baseline were predictors of improved overall survival in our population, independent of known predictors of overall survival such as RPA." @default.
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• W2527685052 date "2016-10-01" @default.
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• W2527685052 title "Prognostic Value of Baseline Quality of Life in Patients Receiving Stereotactic Radiosurgery for Brain Metastases" @default.
• W2527685052 doi "https://doi.org/10.1016/j.ijrobp.2016.06.1941" @default.
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