FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2527831763> ?p ?o ?g. }

• W2527831763 abstract "High-density lipoprotein (HDL) has a signifi- cant cardioprotective effects. HDL induces cyclooxygen- ase-2 (COX-2) expression and prostacyclin I-2 (PGI-2) release in vascular endothelial cells, which contributes to its anti-atherogenic effects. However, the underlying mechanisms are not fully understood. In the present study, we observed that HDL-stimulated COX-2 expression and PGI-2 production in human umbilical vein endothelial cells (HUVECs) in a time- and dose-dependent manner. These effects triggered by HDL were inhibited by pertussis toxin (PTX), protein kinase C (PKC) inhibitor GF109203X, and ERK inhibitor PD98059, suggesting that Gai/Gao-coupled GPCR, PKC, and ERK pathways are involved in HDL- induced COX-2/PGI-2 activation. More importantly, we found that silencing of sphingosine kinase 2 (SphK-2) also blocked HDL-induced COX-2/PGI-2 activation. In addi- tion, HDL-activated SphK-2 phosphorylation accompanied by increased S1P level in the nucleus. Our ChIP data demonstrated that SphK-2 is associated with CREB at the COX-2 promoter region. Collectively, these results indi- cate that HDL induces COX-2 expression and PGI-2 release in endothelial cells through activation of PKC, ERK1/2, and SphK-2 pathways. These findings implicate a novel mechanism underlying anti-atherothrombotic effects of HDL." @default.
• W2527831763 created "2016-10-14" @default.
• W2527831763 creator A5051401482 @default.
• W2527831763 date "2014-01-01" @default.
• W2527831763 modified "2023-09-26" @default.
• W2527831763 title "High-density lipoprotein induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through sphingosine kinase-2" @default.
• W2527831763 cites W1552169997 @default.
• W2527831763 cites W1967600226 @default.
• W2527831763 cites W1967642852 @default.
• W2527831763 cites W1969479668 @default.
• W2527831763 cites W1975447544 @default.
• W2527831763 cites W1988204787 @default.
• W2527831763 cites W1994248356 @default.
• W2527831763 cites W1996605319 @default.
• W2527831763 cites W1998322254 @default.
• W2527831763 cites W1999251984 @default.
• W2527831763 cites W2001026082 @default.
• W2527831763 cites W2009229814 @default.
• W2527831763 cites W2021292814 @default.
• W2527831763 cites W2029343568 @default.
• W2527831763 cites W2029998574 @default.
• W2527831763 cites W2033426513 @default.
• W2527831763 cites W2050388925 @default.
• W2527831763 cites W2061705098 @default.
• W2527831763 cites W2064856877 @default.
• W2527831763 cites W2070482516 @default.
• W2527831763 cites W2071600103 @default.
• W2527831763 cites W2074100282 @default.
• W2527831763 cites W2080605373 @default.
• W2527831763 cites W2080706646 @default.
• W2527831763 cites W2087270884 @default.
• W2527831763 cites W2092576605 @default.
• W2527831763 cites W2102112841 @default.
• W2527831763 cites W2110388058 @default.
• W2527831763 cites W2123915935 @default.
• W2527831763 cites W2126030299 @default.
• W2527831763 cites W2134884423 @default.
• W2527831763 cites W2144473676 @default.
• W2527831763 cites W2144721356 @default.
• W2527831763 cites W2155783652 @default.
• W2527831763 cites W2168743965 @default.
• W2527831763 cites W2169616751 @default.
• W2527831763 cites W2339616051 @default.
• W2527831763 cites W253961800 @default.
• W2527831763 hasPublicationYear "2014" @default.
• W2527831763 type Work @default.
• W2527831763 sameAs 2527831763 @default.
• W2527831763 citedByCount "0" @default.
• W2527831763 crossrefType "journal-article" @default.
• W2527831763 hasAuthorship W2527831763A5051401482 @default.
• W2527831763 hasConcept C104317684 @default.
• W2527831763 hasConcept C126322002 @default.
• W2527831763 hasConcept C134018914 @default.
• W2527831763 hasConcept C1629964 @default.
• W2527831763 hasConcept C170493617 @default.
• W2527831763 hasConcept C181199279 @default.
• W2527831763 hasConcept C184235292 @default.
• W2527831763 hasConcept C185592680 @default.
• W2527831763 hasConcept C195794163 @default.
• W2527831763 hasConcept C202751555 @default.
• W2527831763 hasConcept C2776596873 @default.
• W2527831763 hasConcept C2777411675 @default.
• W2527831763 hasConcept C2778703144 @default.
• W2527831763 hasConcept C2779689624 @default.
• W2527831763 hasConcept C2781128415 @default.
• W2527831763 hasConcept C55493867 @default.
• W2527831763 hasConcept C57074206 @default.
• W2527831763 hasConcept C71924100 @default.
• W2527831763 hasConcept C86339819 @default.
• W2527831763 hasConcept C86803240 @default.
• W2527831763 hasConcept C95444343 @default.
• W2527831763 hasConcept C97029542 @default.
• W2527831763 hasConceptScore W2527831763C104317684 @default.
• W2527831763 hasConceptScore W2527831763C126322002 @default.
• W2527831763 hasConceptScore W2527831763C134018914 @default.
• W2527831763 hasConceptScore W2527831763C1629964 @default.
• W2527831763 hasConceptScore W2527831763C170493617 @default.
• W2527831763 hasConceptScore W2527831763C181199279 @default.
• W2527831763 hasConceptScore W2527831763C184235292 @default.
• W2527831763 hasConceptScore W2527831763C185592680 @default.
• W2527831763 hasConceptScore W2527831763C195794163 @default.
• W2527831763 hasConceptScore W2527831763C202751555 @default.
• W2527831763 hasConceptScore W2527831763C2776596873 @default.
• W2527831763 hasConceptScore W2527831763C2777411675 @default.
• W2527831763 hasConceptScore W2527831763C2778703144 @default.
• W2527831763 hasConceptScore W2527831763C2779689624 @default.
• W2527831763 hasConceptScore W2527831763C2781128415 @default.
• W2527831763 hasConceptScore W2527831763C55493867 @default.
• W2527831763 hasConceptScore W2527831763C57074206 @default.
• W2527831763 hasConceptScore W2527831763C71924100 @default.
• W2527831763 hasConceptScore W2527831763C86339819 @default.
• W2527831763 hasConceptScore W2527831763C86803240 @default.
• W2527831763 hasConceptScore W2527831763C95444343 @default.
• W2527831763 hasConceptScore W2527831763C97029542 @default.
• W2527831763 hasLocation W25278317631 @default.
• W2527831763 hasOpenAccess W2527831763 @default.
• W2527831763 hasPrimaryLocation W25278317631 @default.
• W2527831763 hasRelatedWork W1773820041 @default.
• W2527831763 hasRelatedWork W1965975248 @default.
• W2527831763 hasRelatedWork W1992107070 @default.

• next