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• W2527848247 abstract "Vitamin D deficiency has been reported to be associated with depression, but the underlying mechanisms aren't well understood. Our study aims to investigate the associations among serum vitamin D, C-reactive protein (CRP) level, and depressive symptoms. Serum levels of Vitamin D and CRP were measured from 52,228 participants. Depressive symptoms were assessed using a Korean version of the CES-D scale. We used logistic regression to calculate the odds ratio (ORs) of depressive symptoms according to vitamin D and CRP levels. The regressions were adjusted for covariates, and each model was adjusted mutually for vitamin D and CRP levels. A significant difference was found in vitamin D status between depressed and non-depressed participants, but CRP status was not significantly different. The OR for the presence of depressive symptoms was significantly increased in participants with vitamin D deficiency after adjusting for potentially confounding factors (Adjusted OR = 1.158, 95% CI = 1.003–1.336, p = 0.046). The OR of depressive symptoms was not significantly increased in individuals with high (3.01-10 mg/L) CRP level compared to individuals with low (≤ 3 mg/L) CRP level (Adjusted OR = 1.004, 95% CI = 0.821–1.227, p = 0.97). There was no significant association between vitamin D and CRP level. Additional adjustment for serum CRP level did not weaken the resulting association between vitamin D deficiency and the presence of depressive symptoms. Vitamin D deficiency was associated with depressive symptoms, but elevated serum CRP level was not. The results indicate that CRP level does not account for the association between vitamin D deficiency and the presence of depressive symptoms." @default.
• W2527848247 created "2016-10-14" @default.
• W2527848247 creator A5010636897 @default.
• W2527848247 creator A5044553288 @default.
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• W2527848247 creator A5091466840 @default.
• W2527848247 date "2016-11-01" @default.
• W2527848247 modified "2023-09-25" @default.
• W2527848247 title "The associations among vitamin D deficiency, C-reactive protein, and depressive symptoms" @default.
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• W2527848247 doi "https://doi.org/10.1016/j.jpsychores.2016.10.001" @default.
• W2527848247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27772566" @default.
• W2527848247 hasPublicationYear "2016" @default.
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