Matches in SemOpenAlex for { <https://semopenalex.org/work/W2527853896> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2527853896 endingPage "1023" @default.
- W2527853896 startingPage "1011" @default.
- W2527853896 abstract "Voltage-gated potassium channel (VGKC) complex antibodies are auto-antibodies, initially identified in acquired neuromyotonia (aNMT; Isaacs' syndrome), which cause muscle cramps and difficulty in opening the palm of the hands. Subsequently, these antibodies were found in patients presenting with aNMT along with psychosis, insomnia, and dysautonomia, collectively termed Morvan's syndrome (MoS), and in a limbic encephalopathy (LE) patient with prominent amnesia and frequent seizures. Typical LE cases have a distinctive adult-onset, frequent, brief dystonic seizure semiology that predominantly affects the arms and ipsilateral face. It has now been termed faciobrachial dystonic seizures (FBDS). The VGKC complex is a group of proteins that are strongly associated in situ and after extraction in the mild detergent digitonin. Recent studies indicated that the VGKC complex antibodies are mainly directed toward associated proteins (for example LGI1, Caspr2) that complex with VGKCs themselves. Patients with aNMT or MoS are most likely to have Caspr2 antibodies, whereas LGI1 antibodies are found characteristically in patients with FBDS and LE. We systematically identified and quantified autoantibodies in patient sera with VGKC-complex antibody associated encephalopathy and showed the relationship between individual antibodies and patient's symptoms. Furthermore, we revealed how autoantibodies disrupt the physiological functions of target proteins. LGI1 antibodies neutralize the interaction between LGI1 and ADAM22, reducing the synaptic AMPA receptors." @default.
- W2527853896 created "2016-10-14" @default.
- W2527853896 creator A5043771878 @default.
- W2527853896 date "2016-09-01" @default.
- W2527853896 modified "2023-09-25" @default.
- W2527853896 title "[Voltage-Gated Potassium Channel-Complex Antibodies Associated Encephalopathy and Related Diseases]." @default.
- W2527853896 doi "https://doi.org/10.11477/mf.1416200548" @default.
- W2527853896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27667487" @default.
- W2527853896 hasPublicationYear "2016" @default.
- W2527853896 type Work @default.
- W2527853896 sameAs 2527853896 @default.
- W2527853896 citedByCount "1" @default.
- W2527853896 countsByYear W25278538962018 @default.
- W2527853896 crossrefType "journal-article" @default.
- W2527853896 hasAuthorship W2527853896A5043771878 @default.
- W2527853896 hasConcept C126322002 @default.
- W2527853896 hasConcept C142724271 @default.
- W2527853896 hasConcept C15744967 @default.
- W2527853896 hasConcept C159654299 @default.
- W2527853896 hasConcept C163764329 @default.
- W2527853896 hasConcept C169760540 @default.
- W2527853896 hasConcept C203014093 @default.
- W2527853896 hasConcept C2777699746 @default.
- W2527853896 hasConcept C2778621155 @default.
- W2527853896 hasConcept C2778810854 @default.
- W2527853896 hasConcept C2779134260 @default.
- W2527853896 hasConcept C2779543035 @default.
- W2527853896 hasConcept C71924100 @default.
- W2527853896 hasConceptScore W2527853896C126322002 @default.
- W2527853896 hasConceptScore W2527853896C142724271 @default.
- W2527853896 hasConceptScore W2527853896C15744967 @default.
- W2527853896 hasConceptScore W2527853896C159654299 @default.
- W2527853896 hasConceptScore W2527853896C163764329 @default.
- W2527853896 hasConceptScore W2527853896C169760540 @default.
- W2527853896 hasConceptScore W2527853896C203014093 @default.
- W2527853896 hasConceptScore W2527853896C2777699746 @default.
- W2527853896 hasConceptScore W2527853896C2778621155 @default.
- W2527853896 hasConceptScore W2527853896C2778810854 @default.
- W2527853896 hasConceptScore W2527853896C2779134260 @default.
- W2527853896 hasConceptScore W2527853896C2779543035 @default.
- W2527853896 hasConceptScore W2527853896C71924100 @default.
- W2527853896 hasIssue "9" @default.
- W2527853896 hasLocation W25278538961 @default.
- W2527853896 hasOpenAccess W2527853896 @default.
- W2527853896 hasPrimaryLocation W25278538961 @default.
- W2527853896 hasRelatedWork W1980481988 @default.
- W2527853896 hasRelatedWork W2071623213 @default.
- W2527853896 hasRelatedWork W2085856553 @default.
- W2527853896 hasRelatedWork W2096930184 @default.
- W2527853896 hasRelatedWork W2161714955 @default.
- W2527853896 hasRelatedWork W2424273876 @default.
- W2527853896 hasRelatedWork W2489088384 @default.
- W2527853896 hasRelatedWork W2527853896 @default.
- W2527853896 hasRelatedWork W2943804854 @default.
- W2527853896 hasRelatedWork W3045686840 @default.
- W2527853896 hasVolume "68" @default.
- W2527853896 isParatext "false" @default.
- W2527853896 isRetracted "false" @default.
- W2527853896 magId "2527853896" @default.
- W2527853896 workType "article" @default.