FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2527943968> ?p ?o ?g. }

• W2527943968 endingPage "1323" @default.
• W2527943968 startingPage "1314" @default.
• W2527943968 abstract "The most practical approach to reduce morbidity and mortality of c oronary heart disease (CHD) is to delay the process of thrombus by usage of clot-dissolving  agents . The necessities of such safer compounds are to be critically examined for thrombolytic  activity especially, from marine sources. Thrombolytic agents have been investigated as a possible treatment for thrombus. The aim of this study was to investigate the in vitro thrombolytic potential of Streptomyces sp.VITJS4 (NCIM No. 5574); (ACC No: JQ234978.1) active compounds. The fibrin degradation revealed a clear transparent zone of clearance with 500μg/mL concentration showing 24mm hydrolysis. The thrombolytic effect of Streptomyces sp.VITJS4 compounds was also demonstrated  in vitro clot lysis assay where The percent of thrombolysis by the crude extract showed 90±1.7% at the concentration of 1000µg/mL,  whereas percent of thrombolysis by streptokinase was found 100± 00%%. The bioactive compounds were further studied for spectrophotometric analysis. The UV-VIS profile showed different peaks ranging from 400-700 nm with different absorption respectively. The data confirmed the presence of both analogues with absorption maxima at 210 and 310 nm.  A sensitive method using LC-MS technique was optimized for the separation and identification of bioactive metabolites which was indicated by the fingerprints. The results of the LC-MS analysis provided different peaks determining the presence of compounds with different therapeutic activities.  The current study refers the bioactive compound as impressive thrombolytic agent for further laboratory study. Further studies should be conducted to ensure the efficacy and safety of different concentration of bioactive compounds for drug development. Hence the results reported perhaps useful for the discovery of novel thrombolytic drugs from marine origin." @default.
• W2527943968 created "2016-10-14" @default.
• W2527943968 creator A5000271460 @default.
• W2527943968 creator A5006090162 @default.
• W2527943968 creator A5031451743 @default.
• W2527943968 date "2016-01-01" @default.
• W2527943968 modified "2023-09-26" @default.
• W2527943968 title "In vitro thrombolytic potential of bioactive compounds from marine Streptomyces sp. VITJS4" @default.
• W2527943968 cites W1980561164 @default.
• W2527943968 cites W2003364720 @default.
• W2527943968 cites W2010285210 @default.
• W2527943968 cites W2048474848 @default.
• W2527943968 cites W2074453492 @default.
• W2527943968 cites W2126915932 @default.
• W2527943968 cites W2254065455 @default.
• W2527943968 cites W2990232544 @default.
• W2527943968 doi "https://doi.org/10.14393/bj-v32n1a2016-32683" @default.
• W2527943968 hasPublicationYear "2016" @default.
• W2527943968 type Work @default.
• W2527943968 sameAs 2527943968 @default.
• W2527943968 citedByCount "2" @default.
• W2527943968 countsByYear W25279439682020 @default.
• W2527943968 countsByYear W25279439682022 @default.
• W2527943968 crossrefType "journal-article" @default.
• W2527943968 hasAuthorship W2527943968A5000271460 @default.
• W2527943968 hasAuthorship W2527943968A5006090162 @default.
• W2527943968 hasAuthorship W2527943968A5031451743 @default.
• W2527943968 hasBestOaLocation W25279439681 @default.
• W2527943968 hasConcept C185592680 @default.
• W2527943968 hasConcept C202751555 @default.
• W2527943968 hasConcept C2779920670 @default.
• W2527943968 hasConcept C523546767 @default.
• W2527943968 hasConcept C54355233 @default.
• W2527943968 hasConcept C55493867 @default.
• W2527943968 hasConcept C59822182 @default.
• W2527943968 hasConcept C86803240 @default.
• W2527943968 hasConceptScore W2527943968C185592680 @default.
• W2527943968 hasConceptScore W2527943968C202751555 @default.
• W2527943968 hasConceptScore W2527943968C2779920670 @default.
• W2527943968 hasConceptScore W2527943968C523546767 @default.
• W2527943968 hasConceptScore W2527943968C54355233 @default.
• W2527943968 hasConceptScore W2527943968C55493867 @default.
• W2527943968 hasConceptScore W2527943968C59822182 @default.
• W2527943968 hasConceptScore W2527943968C86803240 @default.
• W2527943968 hasLocation W25279439681 @default.
• W2527943968 hasLocation W25279439682 @default.
• W2527943968 hasOpenAccess W2527943968 @default.
• W2527943968 hasPrimaryLocation W25279439681 @default.
• W2527943968 hasRelatedWork W1602224818 @default.
• W2527943968 hasRelatedWork W2027989916 @default.
• W2527943968 hasRelatedWork W2047134548 @default.
• W2527943968 hasRelatedWork W2119976708 @default.
• W2527943968 hasRelatedWork W2157796563 @default.
• W2527943968 hasRelatedWork W2468335957 @default.
• W2527943968 hasRelatedWork W2979999271 @default.
• W2527943968 hasRelatedWork W3215139134 @default.
• W2527943968 hasRelatedWork W4247921259 @default.
• W2527943968 hasRelatedWork W770724554 @default.
• W2527943968 isParatext "false" @default.
• W2527943968 isRetracted "false" @default.
• W2527943968 magId "2527943968" @default.
• W2527943968 workType "article" @default.