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- W2527993022 endingPage "151" @default.
- W2527993022 startingPage "138" @default.
- W2527993022 abstract "The conversion of 7-dehydrocholesterol to cholesterol, the final step of cholesterol synthesis in the Kandutsch-Russell pathway, is catalyzed by the enzyme 7-dehydrocholesterol reductase (DHCR7). Homozygous or compound heterozygous mutations in DHCR7 lead to the developmental disease Smith-Lemli-Opitz syndrome, which can also result in fetal mortality, highlighting the importance of this enzyme in human development and survival. Besides serving as a substrate for DHCR7, 7-dehydrocholesterol is also a precursor of vitamin D via the action of ultraviolet light on the skin. Thus, DHCR7 exerts complex biological effects, involved in both cholesterol and vitamin D production. Indeed, we argue that DHCR7 can act as a switch between cholesterol and vitamin D synthesis. This review summarizes current knowledge about the critical enzyme DHCR7, highlighting recent findings regarding its structure, transcriptional and post-transcriptional regulation, and its links to vitamin D synthesis. Greater understanding about DHCR7 function, regulation and its place within cellular metabolism will provide important insights into its biological roles." @default.
- W2527993022 created "2016-10-14" @default.
- W2527993022 creator A5021721257 @default.
- W2527993022 creator A5026452363 @default.
- W2527993022 creator A5045502645 @default.
- W2527993022 creator A5082934086 @default.
- W2527993022 creator A5084345521 @default.
- W2527993022 date "2016-10-01" @default.
- W2527993022 modified "2023-10-12" @default.
- W2527993022 title "DHCR7: A vital enzyme switch between cholesterol and vitamin D production" @default.
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