FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528031871> ?p ?o ?g. }

• W2528031871 endingPage "10" @default.
• W2528031871 startingPage "1" @default.
• W2528031871 abstract "Left ventricular systolic dysfunction (LVSD) defined by ejection fraction (EF) <40% is common, serious but treatable, and correct diagnosis is the cornerstone of effective treatment. Biomarkers may help to diagnose LVSD and give insight into the pathophysiology. The immune system is activated in LVSD, and the immunomodulatory molecule human leukocyte antigen-G (HLA-G) may be involved. The primary aim was to measure soluble HLA-G (sHLA-G) in the blood in different stages of LVSD (<30% and 30-40%), in the midrange EF 40-50%, and in preserved EF ≥ 50% and to validate sHLA-G as a LVSD biomarker. The secondary aim was to examine associations between HLA-G gene polymorphisms influencing expression levels and LVSD. The 260 study participants were ≥75 years old, many with risk factors for heart disease or with known heart disease. Soluble HLA-G was significantly and uniformly higher in the groups with EF < 50% (<30, 30-40, and 40-50%) compared to EF > 50% (p < 0.0001). N-terminal fragment-pro-B-type natriuretic peptide (NT-proBNP) and uric acid values were inversely related to EF. According to Receiver Operating Characteristic (ROC) curves NT-proBNP outperformed both sHLA-G and uric acid as biomarkers of LVSD. Soluble HLA-G in blood plasma was elevated in LVSD regardless of EF. A novel finding was that a combined 14 bp ins-del/+3142 SNP HLA-G haplotype was associated with EF < 40%." @default.
• W2528031871 created "2016-10-14" @default.
• W2528031871 creator A5031852383 @default.
• W2528031871 creator A5069249145 @default.
• W2528031871 date "2016-01-01" @default.
• W2528031871 modified "2023-10-18" @default.
• W2528031871 title "Upregulation of Soluble HLA-G in Chronic Left Ventricular Systolic Dysfunction" @default.
• W2528031871 cites W1485420526 @default.
• W2528031871 cites W1892459592 @default.
• W2528031871 cites W1975650161 @default.
• W2528031871 cites W1978005521 @default.
• W2528031871 cites W1990305333 @default.
• W2528031871 cites W1991528894 @default.
• W2528031871 cites W2006184289 @default.
• W2528031871 cites W2016249920 @default.
• W2528031871 cites W2018162126 @default.
• W2528031871 cites W2030678127 @default.
• W2528031871 cites W2038584568 @default.
• W2528031871 cites W2042647165 @default.
• W2528031871 cites W2054639181 @default.
• W2528031871 cites W2057024445 @default.
• W2528031871 cites W2058860683 @default.
• W2528031871 cites W2064483592 @default.
• W2528031871 cites W2066752860 @default.
• W2528031871 cites W2073054137 @default.
• W2528031871 cites W2089785223 @default.
• W2528031871 cites W2091750507 @default.
• W2528031871 cites W2091880298 @default.
• W2528031871 cites W2094872157 @default.
• W2528031871 cites W2098178477 @default.
• W2528031871 cites W2099769151 @default.
• W2528031871 cites W2127501869 @default.
• W2528031871 cites W2130997583 @default.
• W2528031871 cites W2144308706 @default.
• W2528031871 cites W2167666858 @default.
• W2528031871 cites W2219229044 @default.
• W2528031871 cites W2427094903 @default.
• W2528031871 cites W2464111394 @default.
• W2528031871 cites W608522650 @default.
• W2528031871 cites W74654191 @default.
• W2528031871 doi "https://doi.org/10.1155/2016/8417190" @default.
• W2528031871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5075317" @default.
• W2528031871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27800497" @default.
• W2528031871 hasPublicationYear "2016" @default.
• W2528031871 type Work @default.
• W2528031871 sameAs 2528031871 @default.
• W2528031871 citedByCount "6" @default.
• W2528031871 countsByYear W25280318712019 @default.
• W2528031871 countsByYear W25280318712020 @default.
• W2528031871 countsByYear W25280318712021 @default.
• W2528031871 crossrefType "journal-article" @default.
• W2528031871 hasAuthorship W2528031871A5031852383 @default.
• W2528031871 hasAuthorship W2528031871A5069249145 @default.
• W2528031871 hasBestOaLocation W25280318711 @default.
• W2528031871 hasConcept C10162356 @default.
• W2528031871 hasConcept C126322002 @default.
• W2528031871 hasConcept C134018914 @default.
• W2528031871 hasConcept C137061746 @default.
• W2528031871 hasConcept C147483822 @default.
• W2528031871 hasConcept C164705383 @default.
• W2528031871 hasConcept C188280979 @default.
• W2528031871 hasConcept C202751555 @default.
• W2528031871 hasConcept C203014093 @default.
• W2528031871 hasConcept C2775915353 @default.
• W2528031871 hasConcept C2778198053 @default.
• W2528031871 hasConcept C2779881121 @default.
• W2528031871 hasConcept C2781197716 @default.
• W2528031871 hasConcept C55493867 @default.
• W2528031871 hasConcept C58471807 @default.
• W2528031871 hasConcept C71924100 @default.
• W2528031871 hasConcept C78085059 @default.
• W2528031871 hasConcept C86803240 @default.
• W2528031871 hasConcept C8891405 @default.
• W2528031871 hasConceptScore W2528031871C10162356 @default.
• W2528031871 hasConceptScore W2528031871C126322002 @default.
• W2528031871 hasConceptScore W2528031871C134018914 @default.
• W2528031871 hasConceptScore W2528031871C137061746 @default.
• W2528031871 hasConceptScore W2528031871C147483822 @default.
• W2528031871 hasConceptScore W2528031871C164705383 @default.
• W2528031871 hasConceptScore W2528031871C188280979 @default.
• W2528031871 hasConceptScore W2528031871C202751555 @default.
• W2528031871 hasConceptScore W2528031871C203014093 @default.
• W2528031871 hasConceptScore W2528031871C2775915353 @default.
• W2528031871 hasConceptScore W2528031871C2778198053 @default.
• W2528031871 hasConceptScore W2528031871C2779881121 @default.
• W2528031871 hasConceptScore W2528031871C2781197716 @default.
• W2528031871 hasConceptScore W2528031871C55493867 @default.
• W2528031871 hasConceptScore W2528031871C58471807 @default.
• W2528031871 hasConceptScore W2528031871C71924100 @default.
• W2528031871 hasConceptScore W2528031871C78085059 @default.
• W2528031871 hasConceptScore W2528031871C86803240 @default.
• W2528031871 hasConceptScore W2528031871C8891405 @default.
• W2528031871 hasLocation W25280318711 @default.
• W2528031871 hasLocation W25280318712 @default.
• W2528031871 hasLocation W25280318713 @default.
• W2528031871 hasLocation W25280318714 @default.
• W2528031871 hasLocation W25280318715 @default.
• W2528031871 hasOpenAccess W2528031871 @default.

• next