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- W2528058384 abstract "Ticari urun olarak klinik kullanima sunulan bircok ilac verilis yolunma bagli olarak terapotik deger kazanmaktadir. Insanlar tablet ve kapsul gibi konvansiyonel dozaj formlarini, yolculuk gibi nedenlerle su bulamadiklari zamanlarda yutmakta zorlanmaktadirlar. Bu gibi durumlarda kullanilmak uzere agiz boslugunda hizla dagilan tabletler dikkati cekmektedir. Agizda dagilan tabletler, dil uzerine yerlestirildiginde dozaj formu tukuruk vasitasiyla dagilmakta ve ilac cozunmektedir. Kati formdaki ilac hizla cozeltiye donusmekte ve bu durum ilacin emilimini ve etkinin baslamasini hizlandirmaktadir. Formulasyonlar hazirlandiktan sonra elde edilen tabletler; ortalama tablet agirligi ve agirlik tekduzeligi, sertlik, ufalanmaasinma, dagilma zamani, ilac-polimer etkilesimleri, etken madde icerigi, su emme orani, in-vitro ilac salim ozellikleri ve kisa sureli stabilite ozellikleri acisindan degerlendirilmis, FTIR calismalari ve SEM calismalari yapilmistir. F1-F10 olarak isimlendirilen tum formulasyonlarin ortalama tablet agirligi ve agirlik tekduzeligi 253± 0.05 - 291± 0.61 mg, sertligi 2.1± 0.1 - 3.5± 0.07 Kg/cm², ufalanma-asinma yuzdesi % 0.44±0.01 - 0.69±0.01, dagilma zamani 20± 0.08 - 34±1.1 saniye, etken madde icerigi % 92.0 - 99.18, su emme orani 26±1.12 - 49 ± 3.01, islanma zamani 53± 1.89 - 104± 4.89 saniye ve 5 dakika icerisinde in-vitro ilac salim yuzdesi % 85.66 -99.88 olarak belirlenmistir. FTIR calismalari, ilac ve polimer arasinda bir etkilesim olmadigini gostermistir. Stabilite calismalari ilacin farkli sicaklik ve nem ortaminda saklandiginda ilac salim ozelliginin degismedigini gostermistir. Elde edilen sonuclar fuzyon yontemiyle hazirlanan ve klorfeniramin maleat iceren agizda dagilan tabletlerin hizli dissolusyona ugradigini gostermistir." @default.
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- W2528058384 date "2016-09-20" @default.
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- W2528058384 title "Formulation and evaluation of orally dispersible tablets of Chlorpheniramine Maleate by fusion method" @default.
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