Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528202450> ?p ?o ?g. }
- W2528202450 abstract "Hepatitis B virus, with 8 known distinct genotypes, is one of the most serious health problems which results to liver injuries. The surface gene of Hepatitis B virus completely overlaps with the polymerase gene. Mutations in the RT gene result in changes in the overlapping hepatitis B surface antigen.The present study aimed to evaluate the genotypes and prevalence of mutations in a segment of S and RT gene in HBV isolates in Southern Khorasan, Iran.This was a population-based study comprising 5,235 randomized samples for HBV screening. A nested-polymerase chain reaction (PCR) test was followed by direct sequencing, and the sequences blast with present sequences of NCBI database for genotyping. Alignment and phylogenic analysis was performed using MEGA-6 software, and mutation pattern of this segment was finally surveyed in Bioedit software.The mean age was 39.07 ± 14.04 years, with 52.2% female and 47.8% male. All isolates belonged to HBV genotype D, sub-genotype D1. The most amino acid substitutions of surface protein were Q129H (34.42%) and A168V (8.2%), other escape mutants observed in this study were P127L/T, S117G, T125M, S143L, D144E and E164D. In the RT gene, Q149K was the most frequently identified amino acid substitution (9.83%), followed by L122F (8.19%), N118D/T (6.55%), L157M (4.91%), and H124Y (3.27%).This finding represents an ongoing dominancy of HBV genotype D in Eastern Iran, corresponding to other parts of Iran. There were a lot of variations in the S gene leading to an escape mutation, some of which affected the corresponding area of the RT region." @default.
- W2528202450 created "2016-10-14" @default.
- W2528202450 creator A5025487907 @default.
- W2528202450 creator A5058402941 @default.
- W2528202450 creator A5061760754 @default.
- W2528202450 creator A5067458810 @default.
- W2528202450 creator A5083293257 @default.
- W2528202450 date "2016-07-25" @default.
- W2528202450 modified "2023-09-26" @default.
- W2528202450 title "Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran" @default.
- W2528202450 cites W100710130 @default.
- W2528202450 cites W1228830179 @default.
- W2528202450 cites W1968917877 @default.
- W2528202450 cites W1968946492 @default.
- W2528202450 cites W1969760550 @default.
- W2528202450 cites W1984898374 @default.
- W2528202450 cites W1988709996 @default.
- W2528202450 cites W2002827887 @default.
- W2528202450 cites W2012774039 @default.
- W2528202450 cites W2014500655 @default.
- W2528202450 cites W2015269786 @default.
- W2528202450 cites W2020441507 @default.
- W2528202450 cites W2031442917 @default.
- W2528202450 cites W2051306094 @default.
- W2528202450 cites W2061145174 @default.
- W2528202450 cites W2062462673 @default.
- W2528202450 cites W2064695462 @default.
- W2528202450 cites W2068729256 @default.
- W2528202450 cites W2069500319 @default.
- W2528202450 cites W2073478615 @default.
- W2528202450 cites W2084477579 @default.
- W2528202450 cites W2085373422 @default.
- W2528202450 cites W2101437829 @default.
- W2528202450 cites W2102004729 @default.
- W2528202450 cites W2104071028 @default.
- W2528202450 cites W2104181239 @default.
- W2528202450 cites W2109974237 @default.
- W2528202450 cites W2110747022 @default.
- W2528202450 cites W2126494596 @default.
- W2528202450 cites W2127905688 @default.
- W2528202450 cites W2131975358 @default.
- W2528202450 cites W2134011031 @default.
- W2528202450 cites W2138134990 @default.
- W2528202450 cites W2145899386 @default.
- W2528202450 cites W2147894808 @default.
- W2528202450 cites W2151647451 @default.
- W2528202450 cites W2166274558 @default.
- W2528202450 cites W2167651937 @default.
- W2528202450 cites W2183173770 @default.
- W2528202450 cites W2252349832 @default.
- W2528202450 cites W2273840689 @default.
- W2528202450 cites W2348855299 @default.
- W2528202450 cites W2994060018 @default.
- W2528202450 cites W52774379 @default.
- W2528202450 doi "https://doi.org/10.5812/hepatmon.37806" @default.
- W2528202450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5111392" @default.
- W2528202450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27882062" @default.
- W2528202450 hasPublicationYear "2016" @default.
- W2528202450 type Work @default.
- W2528202450 sameAs 2528202450 @default.
- W2528202450 citedByCount "16" @default.
- W2528202450 countsByYear W25282024502016 @default.
- W2528202450 countsByYear W25282024502017 @default.
- W2528202450 countsByYear W25282024502019 @default.
- W2528202450 countsByYear W25282024502020 @default.
- W2528202450 countsByYear W25282024502021 @default.
- W2528202450 countsByYear W25282024502022 @default.
- W2528202450 countsByYear W25282024502023 @default.
- W2528202450 crossrefType "journal-article" @default.
- W2528202450 hasAuthorship W2528202450A5025487907 @default.
- W2528202450 hasAuthorship W2528202450A5058402941 @default.
- W2528202450 hasAuthorship W2528202450A5061760754 @default.
- W2528202450 hasAuthorship W2528202450A5067458810 @default.
- W2528202450 hasAuthorship W2528202450A5083293257 @default.
- W2528202450 hasBestOaLocation W25282024501 @default.
- W2528202450 hasConcept C104317684 @default.
- W2528202450 hasConcept C121332964 @default.
- W2528202450 hasConcept C126322002 @default.
- W2528202450 hasConcept C1276947 @default.
- W2528202450 hasConcept C135763542 @default.
- W2528202450 hasConcept C157431215 @default.
- W2528202450 hasConcept C159047783 @default.
- W2528202450 hasConcept C2522874641 @default.
- W2528202450 hasConcept C2779965577 @default.
- W2528202450 hasConcept C2780593183 @default.
- W2528202450 hasConcept C2781078984 @default.
- W2528202450 hasConcept C2908647359 @default.
- W2528202450 hasConcept C31467283 @default.
- W2528202450 hasConcept C49105822 @default.
- W2528202450 hasConcept C501734568 @default.
- W2528202450 hasConcept C54355233 @default.
- W2528202450 hasConcept C71924100 @default.
- W2528202450 hasConcept C86803240 @default.
- W2528202450 hasConcept C99454951 @default.
- W2528202450 hasConceptScore W2528202450C104317684 @default.
- W2528202450 hasConceptScore W2528202450C121332964 @default.
- W2528202450 hasConceptScore W2528202450C126322002 @default.
- W2528202450 hasConceptScore W2528202450C1276947 @default.
- W2528202450 hasConceptScore W2528202450C135763542 @default.
- W2528202450 hasConceptScore W2528202450C157431215 @default.