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• W2528213069 abstract "Until relatively recently chelating agents have been considered to form a small esoteric group of pharmaceuticals with little relevance to general medicine. Penicillamine, for instance, has been used to treat Wilson's disease for over 35 years, and desferrioxamine has found application for the treatment of transfusion-induced iron overload in thalassaemic patients for almost 20 years. This limited interest is surprising as Fe, Cu, Zn, Ca and Mg all have a critical involvement in cell biochemistry and it would seem likely that chelating agents might find roles in rectifying abnormal distribution of these metals and enhancing their absorption from the gastrointestinal tract. With the postulated involvement of hydroxyl radicals in normal physio­ logical responses as well as a range of disease states (Halliwell and Gutteridge, 1989), clinical interest in the redox active metals Cu and Fe has increased. In principle, selective chelating agents can be designed which scavange non­ protein bound forms of these metals, thereby minimising undesirable hydroxyl radical formation. Such compounds are currently being investigated for the treatment of a wide range of disease states and in this chapter we outline some of these new developments." @default.
• W2528213069 created "2016-10-14" @default.
• W2528213069 creator A5012933721 @default.
• W2528213069 date "1993-01-01" @default.
• W2528213069 modified "2023-09-25" @default.
• W2528213069 title "8 Iron chela tors of clinical significance" @default.
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