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- W2528305152 endingPage "T210" @default.
- W2528305152 startingPage "T199" @default.
- W2528305152 abstract "Androgen receptor splice variants are alternatively spliced variants of androgen receptor, which are C-terminally truncated and lack the canonical ligand-binding domain. Accumulating evidence has indicated a significant role of androgen receptor splice variants in mediating resistance of castration-resistant prostate cancer to current therapies and in predicting therapeutic responses. As such, there is an urgent need to target androgen receptor splicing variants for more effective treatment of castration-resistant prostate cancer. Identification of precise and critical targeting points to deactivate androgen receptor splicing variants relies on a deep understanding of how they are generated and the mechanisms of their action. In this review, we will focus on the emerging data on their generation, clinical significance and mechanisms of action as well as the therapeutic influence of these findings." @default.
- W2528305152 created "2016-10-14" @default.
- W2528305152 creator A5007535547 @default.
- W2528305152 creator A5041851608 @default.
- W2528305152 creator A5084008079 @default.
- W2528305152 date "2016-12-01" @default.
- W2528305152 modified "2023-10-16" @default.
- W2528305152 title "Emerging data on androgen receptor splice variants in prostate cancer" @default.
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