FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528307904> ?p ?o ?g. }

• W2528307904 abstract "Microbial bioprocesses need to be designed to be transferable from lab scale to production scale as well as between setups. Although substantial effort is invested to control technological parameters, usually the only true constant parameter is the actual producer of the product: the cell. Hence, instead of solely controlling technological process parameters, the focus should be increasingly laid on physiological parameters. This contribution aims at illustrating a workflow of data life cycle management with special focus on physiology. Information processing condenses the data into physiological variables, while information mining condenses the variables further into physiological descriptors. This basis facilitates data analysis for a physiological explanation for observed phenomena in productivity. Targeting transferability, we demonstrate this workflow using an industrially relevant Escherichia coli process for recombinant protein production and substantiate the following three points: (1) The postinduction phase is independent in terms of productivity and physiology from the preinduction variables specific growth rate and biomass at induction. (2) The specific substrate uptake rate during induction phase was found to significantly impact the maximum specific product titer. (3) The time point of maximum specific titer can be predicted by an easy accessible physiological variable: while the maximum specific titers were reached at different time points (19.8 ± 7.6 h), those maxima were reached all within a very narrow window of cumulatively consumed substrate dSn (3.1 ± 0.3 g/g). Concluding, this contribution provides a workflow on how to gain a physiological view on the process and illustrates potential benefits. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 33:261-270, 2017." @default.
• W2528307904 created "2016-10-14" @default.
• W2528307904 creator A5020557850 @default.
• W2528307904 creator A5023486351 @default.
• W2528307904 creator A5055332747 @default.
• W2528307904 creator A5061969698 @default.
• W2528307904 date "2016-10-31" @default.
• W2528307904 modified "2023-09-24" @default.
• W2528307904 title "Bioprocess development workflow: Transferable physiological knowledge instead of technological correlations" @default.
• W2528307904 cites W1966866046 @default.
• W2528307904 cites W1967286436 @default.
• W2528307904 cites W1986585052 @default.
• W2528307904 cites W1998154903 @default.
• W2528307904 cites W1998908967 @default.
• W2528307904 cites W2002124595 @default.
• W2528307904 cites W2008764448 @default.
• W2528307904 cites W2011971293 @default.
• W2528307904 cites W2017422800 @default.
• W2528307904 cites W2027708990 @default.
• W2528307904 cites W2029331896 @default.
• W2528307904 cites W2033134248 @default.
• W2528307904 cites W2035198185 @default.
• W2528307904 cites W2056678216 @default.
• W2528307904 cites W2075128186 @default.
• W2528307904 cites W2083551286 @default.
• W2528307904 cites W2093136988 @default.
• W2528307904 cites W2097219388 @default.
• W2528307904 cites W2106436428 @default.
• W2528307904 cites W2116022298 @default.
• W2528307904 cites W2126771677 @default.
• W2528307904 cites W2131273061 @default.
• W2528307904 cites W2133903524 @default.
• W2528307904 cites W2155755249 @default.
• W2528307904 cites W2156581319 @default.
• W2528307904 cites W2157815481 @default.
• W2528307904 cites W2159900080 @default.
• W2528307904 cites W3004335124 @default.
• W2528307904 doi "https://doi.org/10.1002/btpr.2377" @default.
• W2528307904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27690336" @default.
• W2528307904 hasPublicationYear "2016" @default.
• W2528307904 type Work @default.
• W2528307904 sameAs 2528307904 @default.
• W2528307904 citedByCount "3" @default.
• W2528307904 countsByYear W25283079042019 @default.
• W2528307904 countsByYear W25283079042020 @default.
• W2528307904 crossrefType "journal-article" @default.
• W2528307904 hasAuthorship W2528307904A5020557850 @default.
• W2528307904 hasAuthorship W2528307904A5023486351 @default.
• W2528307904 hasAuthorship W2528307904A5055332747 @default.
• W2528307904 hasAuthorship W2528307904A5061969698 @default.
• W2528307904 hasConcept C111919701 @default.
• W2528307904 hasConcept C119857082 @default.
• W2528307904 hasConcept C121332964 @default.
• W2528307904 hasConcept C127413603 @default.
• W2528307904 hasConcept C139719470 @default.
• W2528307904 hasConcept C140331021 @default.
• W2528307904 hasConcept C150903083 @default.
• W2528307904 hasConcept C151730666 @default.
• W2528307904 hasConcept C162324750 @default.
• W2528307904 hasConcept C177212765 @default.
• W2528307904 hasConcept C183696295 @default.
• W2528307904 hasConcept C204983608 @default.
• W2528307904 hasConcept C21880701 @default.
• W2528307904 hasConcept C2778755073 @default.
• W2528307904 hasConcept C41008148 @default.
• W2528307904 hasConcept C4916135 @default.
• W2528307904 hasConcept C61272859 @default.
• W2528307904 hasConcept C62520636 @default.
• W2528307904 hasConcept C77088390 @default.
• W2528307904 hasConcept C86803240 @default.
• W2528307904 hasConcept C98045186 @default.
• W2528307904 hasConceptScore W2528307904C111919701 @default.
• W2528307904 hasConceptScore W2528307904C119857082 @default.
• W2528307904 hasConceptScore W2528307904C121332964 @default.
• W2528307904 hasConceptScore W2528307904C127413603 @default.
• W2528307904 hasConceptScore W2528307904C139719470 @default.
• W2528307904 hasConceptScore W2528307904C140331021 @default.
• W2528307904 hasConceptScore W2528307904C150903083 @default.
• W2528307904 hasConceptScore W2528307904C151730666 @default.
• W2528307904 hasConceptScore W2528307904C162324750 @default.
• W2528307904 hasConceptScore W2528307904C177212765 @default.
• W2528307904 hasConceptScore W2528307904C183696295 @default.
• W2528307904 hasConceptScore W2528307904C204983608 @default.
• W2528307904 hasConceptScore W2528307904C21880701 @default.
• W2528307904 hasConceptScore W2528307904C2778755073 @default.
• W2528307904 hasConceptScore W2528307904C41008148 @default.
• W2528307904 hasConceptScore W2528307904C4916135 @default.
• W2528307904 hasConceptScore W2528307904C61272859 @default.
• W2528307904 hasConceptScore W2528307904C62520636 @default.
• W2528307904 hasConceptScore W2528307904C77088390 @default.
• W2528307904 hasConceptScore W2528307904C86803240 @default.
• W2528307904 hasConceptScore W2528307904C98045186 @default.
• W2528307904 hasLocation W25283079041 @default.
• W2528307904 hasLocation W25283079042 @default.
• W2528307904 hasOpenAccess W2528307904 @default.
• W2528307904 hasPrimaryLocation W25283079041 @default.
• W2528307904 hasRelatedWork W1983927829 @default.
• W2528307904 hasRelatedWork W2020139701 @default.
• W2528307904 hasRelatedWork W2127869220 @default.
• W2528307904 hasRelatedWork W2143268732 @default.

• next