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- W2528317546 abstract "Developmental amnesia (DA) is a selective episodic memory disorder associated with hypoxia-induced bilateral hippocampal atrophy of early onset. Despite the systemic impact of hypoxia-ischaemia, the resulting brain damage was previously reported to be largely limited to the hippocampus. However, the thalamus and the mammillary bodies are parts of the hippocampal-diencephalic network and are therefore also at risk of injury following hypoxic-ischaemic events. Here, we report a neuroimaging investigation of diencephalic damage in a group of 18 patients with DA (age range 11-35 years), and an equal number of controls. Importantly, we uncovered a marked degree of atrophy in the mammillary bodies in two thirds of our patients. In addition, as a group, patients had mildly reduced thalamic volumes. The size of the anterior-mid thalamic (AMT) segment was correlated with patients' visual memory performance. Thus, in addition to the hippocampus, the diencephalic structures also appear to play a role in the patients' memory deficit." @default.
- W2528317546 created "2016-10-14" @default.
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- W2528317546 date "2017-01-01" @default.
- W2528317546 modified "2023-10-12" @default.
- W2528317546 title "Hippocampal and diencephalic pathology in developmental amnesia" @default.
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- W2528317546 doi "https://doi.org/10.1016/j.cortex.2016.09.016" @default.
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