Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528358712> ?p ?o ?g. }
- W2528358712 endingPage "69" @default.
- W2528358712 startingPage "63" @default.
- W2528358712 abstract "The present study aimed to understand the association between erythrocyte membrane alterations and hemolysis in chronic alcoholics. Study was conducted on human male volunteers aged between 35–45 years with a drinking history of 8–10 years. Results showed that plasma marker enzymes AST, ALT, ALP and γGT were increased in alcoholic subjects. Plasma and erythrocyte membrane lipid peroxidation, erythrocyte lysate nitric oxide (NOx) levels were also increased significantly in alcoholics. Furthermore, erythrocyte membrane protein carbonyls, total cholesterol, phospholipid and cholesterol/phospholipid (C/P) ratio were increased in alcoholics. SDS-PAGE analysis of erythrocyte membrane proteins revealed that increased density of band 3, protein 4.2, 4.9, actin and glycophorins, whereas glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and glycophorin A showed slight increase, however, decreased ankyrin with no change in spectrins (α and β) and protein 4.1 densities were observed in alcoholics. Moreover, alcoholics red blood cells showed altered morphology with decreased resistance to osmotic hemolysis. Increased hemolysis showed strong positive association with lipid peroxidation (r = 0.703, p<0.05), protein carbonyls (r = 0.754, p<0.05), lysate NOx (r = 0.654, p<0.05) and weak association with C/P ratio (r = 0.240, p<0.05). Bottom line, increased lipid and protein oxidation, altered membrane C/P ratio and membrane cytoskeletal protein profile might be responsible for the increased hemolysis in alcoholics." @default.
- W2528358712 created "2016-10-14" @default.
- W2528358712 creator A5008230784 @default.
- W2528358712 creator A5009864588 @default.
- W2528358712 creator A5024963180 @default.
- W2528358712 creator A5029260394 @default.
- W2528358712 creator A5046770207 @default.
- W2528358712 creator A5056093369 @default.
- W2528358712 date "2017-01-01" @default.
- W2528358712 modified "2023-09-29" @default.
- W2528358712 title "Association between alcohol-induced erythrocyte membrane alterations and hemolysis in chronic alcoholics" @default.
- W2528358712 cites W1966507838 @default.
- W2528358712 cites W1967694347 @default.
- W2528358712 cites W1976579124 @default.
- W2528358712 cites W1977280882 @default.
- W2528358712 cites W1978249636 @default.
- W2528358712 cites W1986784480 @default.
- W2528358712 cites W1986903834 @default.
- W2528358712 cites W1993889685 @default.
- W2528358712 cites W2001872020 @default.
- W2528358712 cites W2003427997 @default.
- W2528358712 cites W2008091140 @default.
- W2528358712 cites W2010074472 @default.
- W2528358712 cites W2018289835 @default.
- W2528358712 cites W2022961230 @default.
- W2528358712 cites W2031547969 @default.
- W2528358712 cites W2035057079 @default.
- W2528358712 cites W2035936381 @default.
- W2528358712 cites W2037734525 @default.
- W2528358712 cites W2040534221 @default.
- W2528358712 cites W2041477836 @default.
- W2528358712 cites W2046393745 @default.
- W2528358712 cites W2046650033 @default.
- W2528358712 cites W2057512208 @default.
- W2528358712 cites W2070256869 @default.
- W2528358712 cites W2070647828 @default.
- W2528358712 cites W2076519801 @default.
- W2528358712 cites W2078057998 @default.
- W2528358712 cites W2078854975 @default.
- W2528358712 cites W2083496421 @default.
- W2528358712 cites W2097654356 @default.
- W2528358712 cites W2100837269 @default.
- W2528358712 cites W2105369569 @default.
- W2528358712 cites W2112596550 @default.
- W2528358712 cites W2116834525 @default.
- W2528358712 cites W2117422592 @default.
- W2528358712 cites W2120403454 @default.
- W2528358712 cites W2120637506 @default.
- W2528358712 cites W2122386753 @default.
- W2528358712 cites W2126366958 @default.
- W2528358712 cites W2131575626 @default.
- W2528358712 cites W2133197102 @default.
- W2528358712 cites W2135118027 @default.
- W2528358712 cites W2139066937 @default.
- W2528358712 cites W2142514572 @default.
- W2528358712 cites W2154261777 @default.
- W2528358712 cites W2165565317 @default.
- W2528358712 cites W2186502615 @default.
- W2528358712 cites W62597255 @default.
- W2528358712 doi "https://doi.org/10.3164/jcbn.16-16" @default.
- W2528358712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5281527" @default.
- W2528358712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28163384" @default.
- W2528358712 hasPublicationYear "2017" @default.
- W2528358712 type Work @default.
- W2528358712 sameAs 2528358712 @default.
- W2528358712 citedByCount "17" @default.
- W2528358712 countsByYear W25283587122018 @default.
- W2528358712 countsByYear W25283587122019 @default.
- W2528358712 countsByYear W25283587122020 @default.
- W2528358712 countsByYear W25283587122021 @default.
- W2528358712 countsByYear W25283587122022 @default.
- W2528358712 countsByYear W25283587122023 @default.
- W2528358712 crossrefType "journal-article" @default.
- W2528358712 hasAuthorship W2528358712A5008230784 @default.
- W2528358712 hasAuthorship W2528358712A5009864588 @default.
- W2528358712 hasAuthorship W2528358712A5024963180 @default.
- W2528358712 hasAuthorship W2528358712A5029260394 @default.
- W2528358712 hasAuthorship W2528358712A5046770207 @default.
- W2528358712 hasAuthorship W2528358712A5056093369 @default.
- W2528358712 hasBestOaLocation W25283587121 @default.
- W2528358712 hasConcept C126322002 @default.
- W2528358712 hasConcept C134018914 @default.
- W2528358712 hasConcept C142669718 @default.
- W2528358712 hasConcept C144647389 @default.
- W2528358712 hasConcept C1491633281 @default.
- W2528358712 hasConcept C185592680 @default.
- W2528358712 hasConcept C2776151105 @default.
- W2528358712 hasConcept C2776557347 @default.
- W2528358712 hasConcept C2776589458 @default.
- W2528358712 hasConcept C2778163477 @default.
- W2528358712 hasConcept C2778918659 @default.
- W2528358712 hasConcept C2779902561 @default.
- W2528358712 hasConcept C2780829032 @default.
- W2528358712 hasConcept C41625074 @default.
- W2528358712 hasConcept C50244902 @default.
- W2528358712 hasConcept C55493867 @default.
- W2528358712 hasConcept C67982717 @default.
- W2528358712 hasConcept C71924100 @default.