Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528366297> ?p ?o ?g. }
- W2528366297 endingPage "592" @default.
- W2528366297 startingPage "584" @default.
- W2528366297 abstract "Mx (myxovirus resistance) is an important antiviral protein in the innate immune responses of vertebrates to microbial pathogens. In this study, we cloned and characterized Mx1 of black carp (Mylopharyngodon piceus). The full-length cDNA of black carp Mx1 (bcMx1) consists of 2781 nucleotides and the predicted bcMx1 protein contains 631 amino acids. bcMx1 contains a GTPase domain at the N-terminnus, a “central interactive domain” in the middle and a GTPase effector domain at the C-terminus. bcMx1 mRNA was constitutively transcribed in all tissues tested, including the heart, liver, spleen, kidney, intestine, muscle, skin and gill; and bcMx1 mRNA levels increased in all but the gill after grass carp reovirus (GCRV) or viraemia of carp virus (SVCV) infection. Quantitative PCR analysis of Mylopharyngodon piceus fin (MPF) cells indicated that bcMx1 mRNA levels increased after GCRV or SVCV infection at different multiplicities of infection (MOI). Western blotting demonstrated that the molecular weight of bcMx1 is ∼75 kDa and immunofluorescent staining data of both HeLa cells and EPC cells showed that bcMx1 is a cytosolic protein. EPC cells transfected with plasmid expressing bcMx1 showed increased antiviral activity against SVCV and GCRV. All our data suggest that bcMx1 is an antiviral protein in the innate immune response of the black carp." @default.
- W2528366297 created "2016-10-14" @default.
- W2528366297 creator A5021218584 @default.
- W2528366297 creator A5027835055 @default.
- W2528366297 creator A5050409519 @default.
- W2528366297 creator A5057779796 @default.
- W2528366297 creator A5063632964 @default.
- W2528366297 creator A5064592898 @default.
- W2528366297 creator A5081547015 @default.
- W2528366297 date "2016-11-01" @default.
- W2528366297 modified "2023-10-15" @default.
- W2528366297 title "Mx1 of black carp functions importantly in the antiviral innate immune response" @default.
- W2528366297 cites W1019451017 @default.
- W2528366297 cites W1162239908 @default.
- W2528366297 cites W1539385330 @default.
- W2528366297 cites W1570305723 @default.
- W2528366297 cites W1605500799 @default.
- W2528366297 cites W1841861411 @default.
- W2528366297 cites W1968909382 @default.
- W2528366297 cites W1969676810 @default.
- W2528366297 cites W1970822092 @default.
- W2528366297 cites W1971707588 @default.
- W2528366297 cites W1983738417 @default.
- W2528366297 cites W1987561960 @default.
- W2528366297 cites W1993973290 @default.
- W2528366297 cites W1995095014 @default.
- W2528366297 cites W1995744610 @default.
- W2528366297 cites W2004322145 @default.
- W2528366297 cites W2015250229 @default.
- W2528366297 cites W2015459806 @default.
- W2528366297 cites W2015996454 @default.
- W2528366297 cites W2016512423 @default.
- W2528366297 cites W2019019911 @default.
- W2528366297 cites W2023779968 @default.
- W2528366297 cites W2025391846 @default.
- W2528366297 cites W2031913105 @default.
- W2528366297 cites W2034040910 @default.
- W2528366297 cites W2035509260 @default.
- W2528366297 cites W2040579322 @default.
- W2528366297 cites W2041769542 @default.
- W2528366297 cites W2050717638 @default.
- W2528366297 cites W2059372326 @default.
- W2528366297 cites W2062623649 @default.
- W2528366297 cites W2065854688 @default.
- W2528366297 cites W2075413744 @default.
- W2528366297 cites W2090023448 @default.
- W2528366297 cites W2094637827 @default.
- W2528366297 cites W2098672730 @default.
- W2528366297 cites W2099039895 @default.
- W2528366297 cites W2101505589 @default.
- W2528366297 cites W2122224350 @default.
- W2528366297 cites W2134133994 @default.
- W2528366297 cites W2152842365 @default.
- W2528366297 cites W2155180080 @default.
- W2528366297 cites W2155250773 @default.
- W2528366297 cites W2160913295 @default.
- W2528366297 cites W2161355906 @default.
- W2528366297 cites W2168619087 @default.
- W2528366297 cites W2225088467 @default.
- W2528366297 doi "https://doi.org/10.1016/j.fsi.2016.10.002" @default.
- W2528366297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27717902" @default.
- W2528366297 hasPublicationYear "2016" @default.
- W2528366297 type Work @default.
- W2528366297 sameAs 2528366297 @default.
- W2528366297 citedByCount "21" @default.
- W2528366297 countsByYear W25283662972017 @default.
- W2528366297 countsByYear W25283662972018 @default.
- W2528366297 countsByYear W25283662972019 @default.
- W2528366297 countsByYear W25283662972020 @default.
- W2528366297 countsByYear W25283662972021 @default.
- W2528366297 countsByYear W25283662972022 @default.
- W2528366297 countsByYear W25283662972023 @default.
- W2528366297 crossrefType "journal-article" @default.
- W2528366297 hasAuthorship W2528366297A5021218584 @default.
- W2528366297 hasAuthorship W2528366297A5027835055 @default.
- W2528366297 hasAuthorship W2528366297A5050409519 @default.
- W2528366297 hasAuthorship W2528366297A5057779796 @default.
- W2528366297 hasAuthorship W2528366297A5063632964 @default.
- W2528366297 hasAuthorship W2528366297A5064592898 @default.
- W2528366297 hasAuthorship W2528366297A5081547015 @default.
- W2528366297 hasConcept C104317684 @default.
- W2528366297 hasConcept C136449434 @default.
- W2528366297 hasConcept C153911025 @default.
- W2528366297 hasConcept C159047783 @default.
- W2528366297 hasConcept C187882448 @default.
- W2528366297 hasConcept C203014093 @default.
- W2528366297 hasConcept C2778891732 @default.
- W2528366297 hasConcept C2780931953 @default.
- W2528366297 hasConcept C2781257293 @default.
- W2528366297 hasConcept C2909208804 @default.
- W2528366297 hasConcept C505870484 @default.
- W2528366297 hasConcept C55493867 @default.
- W2528366297 hasConcept C86803240 @default.
- W2528366297 hasConcept C8891405 @default.
- W2528366297 hasConceptScore W2528366297C104317684 @default.
- W2528366297 hasConceptScore W2528366297C136449434 @default.
- W2528366297 hasConceptScore W2528366297C153911025 @default.
- W2528366297 hasConceptScore W2528366297C159047783 @default.