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• W2528366928 startingPage "4023" @default.
• W2528366928 abstract "Sensing and responding to environmental cues is critical to the lifestyle of filamentous fungi. How environmental variation influences fungi to produce a wide diversity of ecologically important secondary metabolites (SMs) is not well understood. To address this question, we first examined changes in global gene expression of the opportunistic human pathogen, Aspergillus fumigatus, after exposure to different temperature conditions. We found that 11 of the 37 SM gene clusters in A. fumigatus were expressed at higher levels at 30° than at 37°. We next investigated the role of the light-responsive Velvet complex in environment-dependent gene expression by examining temperature-dependent transcription profiles in the absence of two key members of the Velvet protein complex, VeA and LaeA We found that the 11 temperature-regulated SM gene clusters required VeA at 37° and LaeA at both 30 and 37° for wild-type levels of expression. Interestingly, four SM gene clusters were regulated by VeA at 37° but not at 30°, and two additional ones were regulated by VeA at both temperatures but were substantially less so at 30°, indicating that the role of VeA and, more generally of the Velvet complex, in the regulation of certain SM gene clusters is temperature-dependent. Our findings support the hypothesis that fungal secondary metabolism is regulated by an intertwined network of transcriptional regulators responsive to multiple environmental factors." @default.
• W2528366928 created "2016-10-14" @default.
• W2528366928 creator A5046003244 @default.
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• W2528366928 creator A5076391085 @default.
• W2528366928 date "2016-12-01" @default.
• W2528366928 modified "2023-10-13" @default.
• W2528366928 title "Regulation of Secondary Metabolism by the Velvet Complex Is Temperature-Responsive in <i>Aspergillus</i>" @default.
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• W2528366928 doi "https://doi.org/10.1534/g3.116.033084" @default.
• W2528366928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5144971" @default.
• W2528366928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27694115" @default.
• W2528366928 hasPublicationYear "2016" @default.
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