FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528404703> ?p ?o ?g. }

• W2528404703 endingPage "86" @default.
• W2528404703 startingPage "78" @default.
• W2528404703 abstract "Renin-angiotensin system [RAS] blockade has been established as the cornerstone of therapy in the general population, and especially in chronic kidney disease. However, its efficacy in the kidney transplant population remains unknown.We conducted a systematic review and meta-analysis using MEDLINE (1966 to November 2015), Embase (1980 to November 2015), and the Cochrane Library (third quarter 2015), as well as a PubMed search for recent nonindexed citations.Adult kidney transplant recipients.Randomized controlled trials, with follow-up of 1 year or longer and reporting clinical outcomes of interest.RAS blockade (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) versus placebo, active comparator, or standard of care.All-cause mortality, all-cause transplant failure, and doubling of serum creatinine level.8 trials (1,502 participants) were included in the systematic review. RAS blockade did not significantly alter all-cause mortality (risk ratio [RR], 0.96; 95% CI, 0.62-1.51), transplant failure (RR, 0.76; 95% CI, 0.49-1.18), or creatinine level doubling (RR, 0.84; 95% CI, 0.51-1.39) compared to the control group. This result was robust across the subgroups of interest (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker intervention, follow up ≥ 1 year, and baseline proteinuria as an inclusion criterion). There was significantly higher risk for hyperkalemia with RAS blockade (RR, 2.44; 95% CI, 1.53-3.90). There was no statistical heterogeneity in any of these pooled analyses.Relatively smaller number of events (overall, 71 deaths and 72 transplant failures among 8 trials) and relatively short follow-up (only 2 trials > 5 years).This analysis neither supports nor refutes the hypothesis that RAS blockade improves clinical outcomes in kidney transplant recipients. A trial with more than 10,000 patients would be needed to definitively answer whether RAS blockade reduces transplant loss in this population. In the meantime, clinicians should weigh the risks and benefits of using these medications with their patients on a case-by-case basis." @default.
• W2528404703 created "2016-10-14" @default.
• W2528404703 creator A5013058267 @default.
• W2528404703 creator A5015797368 @default.
• W2528404703 creator A5037863981 @default.
• W2528404703 creator A5046137699 @default.
• W2528404703 creator A5065187538 @default.
• W2528404703 date "2017-01-01" @default.
• W2528404703 modified "2023-10-16" @default.
• W2528404703 title "Renin-Angiotensin System Blockade and Long-term Clinical Outcomes in Kidney Transplant Recipients: A Meta-analysis of Randomized Controlled Trials" @default.
• W2528404703 cites W1514806186 @default.
• W2528404703 cites W1925671649 @default.
• W2528404703 cites W1966688087 @default.
• W2528404703 cites W1984527042 @default.
• W2528404703 cites W1985584629 @default.
• W2528404703 cites W2021334280 @default.
• W2528404703 cites W2033426727 @default.
• W2528404703 cites W2033585778 @default.
• W2528404703 cites W2051833563 @default.
• W2528404703 cites W2056976690 @default.
• W2528404703 cites W2098371593 @default.
• W2528404703 cites W2098923148 @default.
• W2528404703 cites W2107328434 @default.
• W2528404703 cites W2115154092 @default.
• W2528404703 cites W2123074327 @default.
• W2528404703 cites W2125435699 @default.
• W2528404703 cites W2126125759 @default.
• W2528404703 cites W2128216684 @default.
• W2528404703 cites W2134027712 @default.
• W2528404703 cites W2157134953 @default.
• W2528404703 cites W2157823046 @default.
• W2528404703 cites W2159465051 @default.
• W2528404703 cites W2160836591 @default.
• W2528404703 cites W2162304120 @default.
• W2528404703 cites W2174912211 @default.
• W2528404703 cites W2271446173 @default.
• W2528404703 cites W2334803307 @default.
• W2528404703 cites W2615684303 @default.
• W2528404703 cites W3021250193 @default.
• W2528404703 cites W4294215472 @default.
• W2528404703 doi "https://doi.org/10.1053/j.ajkd.2016.08.018" @default.
• W2528404703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27712852" @default.
• W2528404703 hasPublicationYear "2017" @default.
• W2528404703 type Work @default.
• W2528404703 sameAs 2528404703 @default.
• W2528404703 citedByCount "60" @default.
• W2528404703 countsByYear W25284047032017 @default.
• W2528404703 countsByYear W25284047032018 @default.
• W2528404703 countsByYear W25284047032019 @default.
• W2528404703 countsByYear W25284047032020 @default.
• W2528404703 countsByYear W25284047032021 @default.
• W2528404703 countsByYear W25284047032022 @default.
• W2528404703 countsByYear W25284047032023 @default.
• W2528404703 crossrefType "journal-article" @default.
• W2528404703 hasAuthorship W2528404703A5013058267 @default.
• W2528404703 hasAuthorship W2528404703A5015797368 @default.
• W2528404703 hasAuthorship W2528404703A5037863981 @default.
• W2528404703 hasAuthorship W2528404703A5046137699 @default.
• W2528404703 hasAuthorship W2528404703A5065187538 @default.
• W2528404703 hasConcept C104849204 @default.
• W2528404703 hasConcept C126322002 @default.
• W2528404703 hasConcept C168563851 @default.
• W2528404703 hasConcept C2776478404 @default.
• W2528404703 hasConcept C2778653478 @default.
• W2528404703 hasConcept C2908647359 @default.
• W2528404703 hasConcept C2908929049 @default.
• W2528404703 hasConcept C71924100 @default.
• W2528404703 hasConcept C84393581 @default.
• W2528404703 hasConcept C99454951 @default.
• W2528404703 hasConceptScore W2528404703C104849204 @default.
• W2528404703 hasConceptScore W2528404703C126322002 @default.
• W2528404703 hasConceptScore W2528404703C168563851 @default.
• W2528404703 hasConceptScore W2528404703C2776478404 @default.
• W2528404703 hasConceptScore W2528404703C2778653478 @default.
• W2528404703 hasConceptScore W2528404703C2908647359 @default.
• W2528404703 hasConceptScore W2528404703C2908929049 @default.
• W2528404703 hasConceptScore W2528404703C71924100 @default.
• W2528404703 hasConceptScore W2528404703C84393581 @default.
• W2528404703 hasConceptScore W2528404703C99454951 @default.
• W2528404703 hasIssue "1" @default.
• W2528404703 hasLocation W25284047031 @default.
• W2528404703 hasLocation W25284047032 @default.
• W2528404703 hasOpenAccess W2528404703 @default.
• W2528404703 hasPrimaryLocation W25284047031 @default.
• W2528404703 hasRelatedWork W1503553695 @default.
• W2528404703 hasRelatedWork W2507295142 @default.
• W2528404703 hasRelatedWork W2897414996 @default.
• W2528404703 hasRelatedWork W2920090081 @default.
• W2528404703 hasRelatedWork W2981884515 @default.
• W2528404703 hasRelatedWork W2989921235 @default.
• W2528404703 hasRelatedWork W3003571257 @default.
• W2528404703 hasRelatedWork W3159250744 @default.
• W2528404703 hasRelatedWork W4292236216 @default.
• W2528404703 hasRelatedWork W1556208436 @default.
• W2528404703 hasVolume "69" @default.
• W2528404703 isParatext "false" @default.
• W2528404703 isRetracted "false" @default.
• W2528404703 magId "2528404703" @default.

• next