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• W2528441423 endingPage "2086" @default.
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• W2528441423 abstract "2086 Background: Circulating endothelial cells (CECs) have prognostic and predictive value in breast cancer patients treated with metronomic chemotherapy. High levels of microparticles (MPs) are associated to shorter survival in prostate cancer. We investigated the pre- and posttreatment levels of CECs, MPs and several inflammation and coagulation markers in patients with newly diagnosed glioblastoma (GB) who received protracted temozolomide (PTMZ) and radiotherapy (RT). Methods: Peripheral blood was obtained from 14 patients with GB before and 4-5 weeks after beginning of treatment. Healthy subjects (n = 22) were used as controls. Isolation and quantification of CECs were determined by an immunomagnetic technique using CD146 and lectin-1 of Ulex Europaeus combined with fluorescein. Flow cytometry of plasma was used for detection of total phosphatidylserine-positive MPs, labeled with FITC-Annexin V. Endogen thrombin generation (ETG) was measured by the calibrated automated thrombogram method (CAT). Prothrombin fragment 1+2 (F1+2) and interleukin-6 (IL-6) were measured by ELISA. Results: Mean number of CECs was significantly increased in patients before (112 ± 65 cells/mL) and after treatment (122 ± 80 cell/mL) as compared to controls (10 ± 5 cell/mL; p < 0.0001). Mean number of MPs was significantly increased in patients before (794 ± 573 MPs/μ L) and after treatment (408 ± 207 MPs/μ L) as compared to controls (234 ± 174 MPs/μ L; p < 0.05). Levels of IL-6 were significantly higher in patients before and after treatment (IL6, 8.3 ± 14.3 pg/mL; 3.2 ± 3.1 pg/mL) than in controls (0.9 ± 0.8 pg/mL). Levels of coagulation markers were significantly higher in patients before treatment (F1+2, 0.33 ± 0.18 pmol/mL; ETG, 234 ± 106 nM). However, levels of both markers decreased near normal values (F1+2, 0.22 ± 0.07 vs. 0.17 ± 0.04 pmol/mL; ETG, 169 ± 146 vs. 162 ± 72 nM) after treatment. Conclusions: CECs and MPs, as well as a set of markers of inflammation and coagulation, are strongly elevated in patients with GB. Coagulation markers decrease after treatment with PTMZ+RT. The influence of treatment on CEC and MP levels is unclear and needs further study. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Schering-Plough Schering-Plough" @default.
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• W2528441423 date "2010-05-20" @default.
• W2528441423 modified "2023-10-17" @default.
• W2528441423 title "Circulating endothelial cells, microparticles, and markers of inflammation and coagulation in glioblastoma patients before and after protracted temozolomide and radiotherapy." @default.
• W2528441423 doi "https://doi.org/10.1200/jco.2010.28.15_suppl.2086" @default.
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