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• W2528589040 abstract "Summary The role of second hand smoke ( SHS ) exposure on ulcerative colitis is not known. Our aim was to examine the effects of α‐lipoic acid ( ALA ), chronic aerobic ( AE ) or resistance exercise ( RE ) on SHS exposed rats with colitis. Sprague‐Dawley male rats (150‐200 g, n=54) were selected for colitis induction. Among the colitis groups, one group was exposed to SHS (6 d/wk, 4 cigarettes/d) and the other was not. The SHS group was divided into subgroups as follows: sedentary; AE (swimming; 3 d/wk); and RE (climbing with weight; 3 d/wk). After 5 weeks, colitis was induced by intrarectal acetic acid. All groups had subgroups that were given subcutaneously ALA (50 mg/kg per day) or vehicle for 3 days. Following decapitation, colon tissues were sampled to examine malondialdehyde ( MDA ) and glutathione ( GSH ) levels, myeloperoxidase ( MPO ) activity, luminol and lucigenin chemiluminenscence, macroscopic scoring and histologic examination. ANOVA and Student's t ‐test were used for statistical analysis. The increased macroscopic and microscopic scores, MPO , MDA , luminol and lucigenin measurements in colitis and SHS ‐colitis groups were decreased via ALA ( P <.05‐.001). AE declined macroscopic and microscopic scores, MDA , lucigenin compared to colitis and SHS ‐colitis groups ( P <.01‐.001). RE reduced microscopic score, MPO , MDA , luminol, lucigenin ( P <.05‐.001) that were increased with colitis. Decreased GSH levels ( P <.01) in the SHS ‐colitis group approached to control levels when given ALA . According to our results SHS and colitis induction increased inflammatory damage. SHS did not worsen it more than colitis. Our results suggest that ALA , AE or RE might be protective for SHS exposed ulcerative colitis conditions." @default.
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• W2528589040 date "2016-12-27" @default.
• W2528589040 modified "2023-10-17" @default.
• W2528589040 title "Protective effect of alpha-lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats" @default.
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• W2528589040 doi "https://doi.org/10.1111/1440-1681.12682" @default.
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