FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528590902> ?p ?o ?g. }

• W2528590902 endingPage "753" @default.
• W2528590902 startingPage "737" @default.
• W2528590902 abstract "Abstract Background Acute worsening of asthma symptoms (exacerbation) is predominantly triggered by respiratory viruses, with influenza causing the most severe exacerbations. The lack of an adequate animal model hampers mechanistic insight and the development of new therapeutics. Aim We developed and characterized a robust, consistent, and reproducible mouse model of severe exacerbation of chronic allergic asthma. Methods Chronic allergic airway inflammation was induced following a house dust mite ( HDM ) sensitization protocol. HDM ‐sensitized mice and controls were infected with influenza virus A/X31 H3N2 and either or not treated with inhaled fluticasone propionate ( FP ), systemic corticosteroids (Pred), or anti‐ IL ‐5. Mice were killed at different time points after infection: Cellular accumulation and cytokines levels in the airways, PenH as a measure of airway hyper‐responsiveness ( AHR ), and lung histology and viral replication were assessed. Results Infection with low‐dose A/X31 H3N2 led to prolonged deterioration of lung function, aggravated mucus production, peri‐vascular, peri‐bronchial, and allergic inflammation that was unresponsive to inhaled corticosteroids, but responsive to systemic corticosteroids. The exacerbation was preceded at 14 h after virus exposure by a marked innate, but no Th2 and Th1 response subsequently followed by enhanced numbers of eosinophils, neutrophils, dendritic, and T cells into the lung lumen, parenchyma, and draining lymph nodes in HDM ‐sensitized mice. Anti‐ IL ‐5 treatment attenuated eosinophils and prevented the X31‐induced exacerbation. Conclusions Together, these findings indicate that an early innate response that involves eosinophils underlies the exacerbation. This model recapitulates all major features of severe asthma exacerbations and can serve to discern driving mechanisms and promote the development of novel therapeutics." @default.
• W2528590902 created "2016-10-14" @default.
• W2528590902 creator A5003358525 @default.
• W2528590902 creator A5013503198 @default.
• W2528590902 creator A5025153030 @default.
• W2528590902 creator A5027155514 @default.
• W2528590902 creator A5043940021 @default.
• W2528590902 creator A5044455625 @default.
• W2528590902 creator A5060666129 @default.
• W2528590902 creator A5061580568 @default.
• W2528590902 creator A5063587197 @default.
• W2528590902 creator A5068120833 @default.
• W2528590902 creator A5081302632 @default.
• W2528590902 creator A5087386233 @default.
• W2528590902 creator A5091690733 @default.
• W2528590902 creator A5091761903 @default.
• W2528590902 date "2016-11-10" @default.
• W2528590902 modified "2023-10-16" @default.
• W2528590902 title "An early innate response underlies severe influenza-induced exacerbations of asthma in a novel steroid-insensitive and anti-IL-5-responsive mouse model" @default.
• W2528590902 cites W1767689587 @default.
• W2528590902 cites W1964779747 @default.
• W2528590902 cites W1967399138 @default.
• W2528590902 cites W1969175063 @default.
• W2528590902 cites W1970180138 @default.
• W2528590902 cites W1970703972 @default.
• W2528590902 cites W1982352830 @default.
• W2528590902 cites W1988758075 @default.
• W2528590902 cites W1998275944 @default.
• W2528590902 cites W2004183112 @default.
• W2528590902 cites W2037801848 @default.
• W2528590902 cites W2040242624 @default.
• W2528590902 cites W2043990114 @default.
• W2528590902 cites W2059861899 @default.
• W2528590902 cites W2064598476 @default.
• W2528590902 cites W2065220920 @default.
• W2528590902 cites W2066391003 @default.
• W2528590902 cites W2067222999 @default.
• W2528590902 cites W2075699130 @default.
• W2528590902 cites W2082697031 @default.
• W2528590902 cites W2093268042 @default.
• W2528590902 cites W2095754126 @default.
• W2528590902 cites W2098276532 @default.
• W2528590902 cites W2098603057 @default.
• W2528590902 cites W2100197170 @default.
• W2528590902 cites W2102345655 @default.
• W2528590902 cites W2102421151 @default.
• W2528590902 cites W2104845020 @default.
• W2528590902 cites W2105755794 @default.
• W2528590902 cites W2106980654 @default.
• W2528590902 cites W2113025135 @default.
• W2528590902 cites W2117905696 @default.
• W2528590902 cites W2122172797 @default.
• W2528590902 cites W2126411802 @default.
• W2528590902 cites W2142495381 @default.
• W2528590902 cites W2150925133 @default.
• W2528590902 cites W2155703113 @default.
• W2528590902 cites W2164191624 @default.
• W2528590902 cites W2210562492 @default.
• W2528590902 cites W2286627591 @default.
• W2528590902 cites W2334648785 @default.
• W2528590902 cites W2413509025 @default.
• W2528590902 cites W4319308391 @default.
• W2528590902 doi "https://doi.org/10.1111/all.13057" @default.
• W2528590902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27696462" @default.
• W2528590902 hasPublicationYear "2016" @default.
• W2528590902 type Work @default.
• W2528590902 sameAs 2528590902 @default.
• W2528590902 citedByCount "31" @default.
• W2528590902 countsByYear W25285909022017 @default.
• W2528590902 countsByYear W25285909022018 @default.
• W2528590902 countsByYear W25285909022019 @default.
• W2528590902 countsByYear W25285909022020 @default.
• W2528590902 countsByYear W25285909022021 @default.
• W2528590902 countsByYear W25285909022022 @default.
• W2528590902 countsByYear W25285909022023 @default.
• W2528590902 crossrefType "journal-article" @default.
• W2528590902 hasAuthorship W2528590902A5003358525 @default.
• W2528590902 hasAuthorship W2528590902A5013503198 @default.
• W2528590902 hasAuthorship W2528590902A5025153030 @default.
• W2528590902 hasAuthorship W2528590902A5027155514 @default.
• W2528590902 hasAuthorship W2528590902A5043940021 @default.
• W2528590902 hasAuthorship W2528590902A5044455625 @default.
• W2528590902 hasAuthorship W2528590902A5060666129 @default.
• W2528590902 hasAuthorship W2528590902A5061580568 @default.
• W2528590902 hasAuthorship W2528590902A5063587197 @default.
• W2528590902 hasAuthorship W2528590902A5068120833 @default.
• W2528590902 hasAuthorship W2528590902A5081302632 @default.
• W2528590902 hasAuthorship W2528590902A5087386233 @default.
• W2528590902 hasAuthorship W2528590902A5091690733 @default.
• W2528590902 hasAuthorship W2528590902A5091761903 @default.
• W2528590902 hasBestOaLocation W25285909022 @default.
• W2528590902 hasConcept C136449434 @default.
• W2528590902 hasConcept C203014093 @default.
• W2528590902 hasConcept C207480886 @default.
• W2528590902 hasConcept C2522874641 @default.
• W2528590902 hasConcept C2776042228 @default.
• W2528590902 hasConcept C2776051438 @default.
• W2528590902 hasConcept C2777014857 @default.

• next