FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528695280> ?p ?o ?g. }

• W2528695280 endingPage "1784" @default.
• W2528695280 startingPage "1776" @default.
• W2528695280 abstract "We determined the gene expression profiles for 48 ATP binding cassette ( ABC ) transporters in matched colon cancer and normal colon tissues in order to provide insight into the mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCB 1 , ABCC 1 , ABCC 2 , ABCC 3 , and ABCG 2 was altered in association with colon carcinogenesis. Among these transporters, the expression of ABCC 3 was repressed by Wnt signaling pathway in colon cancer cell lines. Knockdown of the pathway components transcription factor 7‐like 2 ( TCF 7L2) or β‐catenin thus increased ABCC 3 expression, whereas activation of Wnt signaling with inhibitors of glycogen synthase kinase–3β ( GSK ‐3β) reduced it. Ch IP and luciferase reporter assays also showed that TCF 7L2 binds to the ABCC 3 locus and regulates its expression. Finally, overexpression of ABCC 3 in colon cancer cells conferred resistance to anticancer drug‐induced cytotoxicity. Our data thus suggest that Wnt signaling represses ABCC 3 expression during colon carcinogenesis, and that subsequent upregulation of ABCC 3 expression during drug treatment might contribute to acquired drug resistance." @default.
• W2528695280 created "2016-10-14" @default.
• W2528695280 creator A5002141885 @default.
• W2528695280 creator A5045423153 @default.
• W2528695280 creator A5053003549 @default.
• W2528695280 creator A5060059918 @default.
• W2528695280 creator A5086139902 @default.
• W2528695280 date "2016-12-01" @default.
• W2528695280 modified "2023-10-06" @default.
• W2528695280 title "Wnt‐β‐catenin signaling regulates <scp>ABCC</scp> 3 ( <scp>MRP</scp> 3) transporter expression in colorectal cancer" @default.
• W2528695280 cites W1992292837 @default.
• W2528695280 cites W1992867510 @default.
• W2528695280 cites W1997994412 @default.
• W2528695280 cites W2001258296 @default.
• W2528695280 cites W2006434892 @default.
• W2528695280 cites W2012184780 @default.
• W2528695280 cites W2042280256 @default.
• W2528695280 cites W2050767064 @default.
• W2528695280 cites W2058093850 @default.
• W2528695280 cites W2069703793 @default.
• W2528695280 cites W2096204304 @default.
• W2528695280 cites W2100999040 @default.
• W2528695280 cites W2103847098 @default.
• W2528695280 cites W2108808690 @default.
• W2528695280 cites W2121543823 @default.
• W2528695280 cites W2126504523 @default.
• W2528695280 cites W2128502368 @default.
• W2528695280 cites W2137457318 @default.
• W2528695280 cites W2163691988 @default.
• W2528695280 cites W2164222087 @default.
• W2528695280 cites W2482898552 @default.
• W2528695280 doi "https://doi.org/10.1111/cas.13097" @default.
• W2528695280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5198960" @default.
• W2528695280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27709738" @default.
• W2528695280 hasPublicationYear "2016" @default.
• W2528695280 type Work @default.
• W2528695280 sameAs 2528695280 @default.
• W2528695280 citedByCount "32" @default.
• W2528695280 countsByYear W25286952802017 @default.
• W2528695280 countsByYear W25286952802018 @default.
• W2528695280 countsByYear W25286952802019 @default.
• W2528695280 countsByYear W25286952802020 @default.
• W2528695280 countsByYear W25286952802021 @default.
• W2528695280 countsByYear W25286952802022 @default.
• W2528695280 countsByYear W25286952802023 @default.
• W2528695280 crossrefType "journal-article" @default.
• W2528695280 hasAuthorship W2528695280A5002141885 @default.
• W2528695280 hasAuthorship W2528695280A5045423153 @default.
• W2528695280 hasAuthorship W2528695280A5053003549 @default.
• W2528695280 hasAuthorship W2528695280A5060059918 @default.
• W2528695280 hasAuthorship W2528695280A5086139902 @default.
• W2528695280 hasBestOaLocation W25286952801 @default.
• W2528695280 hasConcept C104317684 @default.
• W2528695280 hasConcept C121608353 @default.
• W2528695280 hasConcept C137620995 @default.
• W2528695280 hasConcept C149011108 @default.
• W2528695280 hasConcept C153911025 @default.
• W2528695280 hasConcept C173396325 @default.
• W2528695280 hasConcept C30145163 @default.
• W2528695280 hasConcept C44312359 @default.
• W2528695280 hasConcept C502942594 @default.
• W2528695280 hasConcept C526805850 @default.
• W2528695280 hasConcept C54355233 @default.
• W2528695280 hasConcept C555283112 @default.
• W2528695280 hasConcept C62478195 @default.
• W2528695280 hasConcept C81885089 @default.
• W2528695280 hasConcept C86803240 @default.
• W2528695280 hasConcept C95444343 @default.
• W2528695280 hasConceptScore W2528695280C104317684 @default.
• W2528695280 hasConceptScore W2528695280C121608353 @default.
• W2528695280 hasConceptScore W2528695280C137620995 @default.
• W2528695280 hasConceptScore W2528695280C149011108 @default.
• W2528695280 hasConceptScore W2528695280C153911025 @default.
• W2528695280 hasConceptScore W2528695280C173396325 @default.
• W2528695280 hasConceptScore W2528695280C30145163 @default.
• W2528695280 hasConceptScore W2528695280C44312359 @default.
• W2528695280 hasConceptScore W2528695280C502942594 @default.
• W2528695280 hasConceptScore W2528695280C526805850 @default.
• W2528695280 hasConceptScore W2528695280C54355233 @default.
• W2528695280 hasConceptScore W2528695280C555283112 @default.
• W2528695280 hasConceptScore W2528695280C62478195 @default.
• W2528695280 hasConceptScore W2528695280C81885089 @default.
• W2528695280 hasConceptScore W2528695280C86803240 @default.
• W2528695280 hasConceptScore W2528695280C95444343 @default.
• W2528695280 hasIssue "12" @default.
• W2528695280 hasLocation W25286952801 @default.
• W2528695280 hasLocation W25286952802 @default.
• W2528695280 hasLocation W25286952803 @default.
• W2528695280 hasOpenAccess W2528695280 @default.
• W2528695280 hasPrimaryLocation W25286952801 @default.
• W2528695280 hasRelatedWork W1482045571 @default.
• W2528695280 hasRelatedWork W1604610285 @default.
• W2528695280 hasRelatedWork W2009139774 @default.
• W2528695280 hasRelatedWork W2023146604 @default.
• W2528695280 hasRelatedWork W2079328056 @default.
• W2528695280 hasRelatedWork W2109111352 @default.
• W2528695280 hasRelatedWork W2135194872 @default.
• W2528695280 hasRelatedWork W2237818184 @default.

• next