FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528720107> ?p ?o ?g. }

• W2528720107 endingPage "85" @default.
• W2528720107 startingPage "78" @default.
• W2528720107 abstract "Transscleral drug delivery may become a safe alternative to the intravitreal injection for chronic retinal diseases such as age-related macular degeneration or diabetic macular edema. However, the drug delivered onto the sclera subjects to vigorous clearance by episcleral and choroidal circulation; in addition, the penetration from episclera to retina needs to overcome counter-directional ocular fluid current driven by intraocular pressure (IOP) as well as unfavorable drug disposition exerted by drug transporters before the drug reach retina. It is imperative to understand these processes and quantitate their influence for efficient designing of a sustained formulation or device to achieve efficient transscleral drug delivery. The current study was focused on the effects of intraocular pressure (IOP) and choroidal circulation on transscleral drug delivery using triamcinolone acetonide (TA) as a model drug. Rabbit eye IOP was modulated through cannulation in ex vivo study or through cryopexy of ciliary body in vivo studies before subtenon TA injection or episcleral TA-film implantation. In a subgroup of the rabbit eyes, localized choroid atrophy was induced by cryopexy before TA-film implantation. Each condition had a concurrent control group. The vitreous TA concentration was quantitated by ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC/MS/MS). The vitreous TA concentration was compared between the study and control groups for effect of IOP or choroid circulation. For ex vivo studies, higher IOP was a significant effect against TA penetration from episclera towards vitreous. TA was 8.5±5ng/mL in receptor chamber with a cross pressure of 50mmHg versus 15.9±10ng/mL with the cross pressure of 5mmHg; p=0.001, t-test. A multivariate regression demonstrated each mmHg of IOP increase would result in 3ng/mL lower concentration in the receptor chamber. Similar IOP effect was also identified in a 3-hour study using euthanized rabbit eyes whose IOP was controlled at 10 or 40mmHg by cannulation (3261±1821ng/mL vs. 755±763ng/mL; p=0.013, Wilcoxon test). However, the effect of IOP was not significant in alive animal with the same IOP setting. In vivo chronic study using low IOP (7.7mmHg) versus normal IOP (14.4mmHg), vitreous TA was not statistically significant (154±200ng/mL vs. 80±130ng/mL, p=0.17, Wilcoxon test). However, removing of choroidal circulation by local cryopexy significantly enhanced the TA penetration from episclera to vitreous (mean 163±129.8ng/mL for choroidal cryopexy vs. 81.8±37.2ng/mL for ciliary cryopexy or 75.5±36ng/mL for control group, p=0.007, regression analysis). In conclusion, the effect of IOP on transscleral drug delivery was not a significant effect in alive rabbit eyes; however, choroidal circulation seems to be a significant effect to affect TA penetration from episclera towards retina and vitreous." @default.
• W2528720107 created "2016-10-14" @default.
• W2528720107 creator A5014527386 @default.
• W2528720107 creator A5018825933 @default.
• W2528720107 creator A5036612595 @default.
• W2528720107 creator A5039226147 @default.
• W2528720107 creator A5039407742 @default.
• W2528720107 creator A5056093254 @default.
• W2528720107 date "2016-12-01" @default.
• W2528720107 modified "2023-09-24" @default.
• W2528720107 title "Effect of intraocular pressure (IOP) and choroidal circulation on controlled episcleral drug delivery to retina/vitreous" @default.
• W2528720107 cites W1500728559 @default.
• W2528720107 cites W1502916649 @default.
• W2528720107 cites W1570409021 @default.
• W2528720107 cites W180812339 @default.
• W2528720107 cites W1809125639 @default.
• W2528720107 cites W1937752367 @default.
• W2528720107 cites W1967801099 @default.
• W2528720107 cites W1988468032 @default.
• W2528720107 cites W1997156360 @default.
• W2528720107 cites W1998143558 @default.
• W2528720107 cites W1998494232 @default.
• W2528720107 cites W2004209831 @default.
• W2528720107 cites W2005391764 @default.
• W2528720107 cites W2007155254 @default.
• W2528720107 cites W2010804179 @default.
• W2528720107 cites W2013228856 @default.
• W2528720107 cites W2016393330 @default.
• W2528720107 cites W2022793570 @default.
• W2528720107 cites W2025450854 @default.
• W2528720107 cites W2027533088 @default.
• W2528720107 cites W2029056867 @default.
• W2528720107 cites W2037509680 @default.
• W2528720107 cites W2039214400 @default.
• W2528720107 cites W2040236977 @default.
• W2528720107 cites W2056970085 @default.
• W2528720107 cites W2064268032 @default.
• W2528720107 cites W2066077017 @default.
• W2528720107 cites W2066865635 @default.
• W2528720107 cites W2067055244 @default.
• W2528720107 cites W2078626825 @default.
• W2528720107 cites W2089851347 @default.
• W2528720107 cites W2094102770 @default.
• W2528720107 cites W2123008745 @default.
• W2528720107 cites W2123790418 @default.
• W2528720107 cites W2125770993 @default.
• W2528720107 cites W2134175990 @default.
• W2528720107 cites W2145072487 @default.
• W2528720107 cites W2145923696 @default.
• W2528720107 cites W2148122533 @default.
• W2528720107 cites W2152957810 @default.
• W2528720107 cites W2160226180 @default.
• W2528720107 cites W2318378557 @default.
• W2528720107 doi "https://doi.org/10.1016/j.jconrel.2016.10.001" @default.
• W2528720107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27717742" @default.
• W2528720107 hasPublicationYear "2016" @default.
• W2528720107 type Work @default.
• W2528720107 sameAs 2528720107 @default.
• W2528720107 citedByCount "6" @default.
• W2528720107 countsByYear W25287201072017 @default.
• W2528720107 countsByYear W25287201072018 @default.
• W2528720107 countsByYear W25287201072020 @default.
• W2528720107 countsByYear W25287201072021 @default.
• W2528720107 crossrefType "journal-article" @default.
• W2528720107 hasAuthorship W2528720107A5014527386 @default.
• W2528720107 hasAuthorship W2528720107A5018825933 @default.
• W2528720107 hasAuthorship W2528720107A5036612595 @default.
• W2528720107 hasAuthorship W2528720107A5039226147 @default.
• W2528720107 hasAuthorship W2528720107A5039407742 @default.
• W2528720107 hasAuthorship W2528720107A5056093254 @default.
• W2528720107 hasConcept C118487528 @default.
• W2528720107 hasConcept C169760540 @default.
• W2528720107 hasConcept C178790620 @default.
• W2528720107 hasConcept C185592680 @default.
• W2528720107 hasConcept C2776694393 @default.
• W2528720107 hasConcept C2777093970 @default.
• W2528720107 hasConcept C2777100477 @default.
• W2528720107 hasConcept C2778434524 @default.
• W2528720107 hasConcept C2778903070 @default.
• W2528720107 hasConcept C2779820397 @default.
• W2528720107 hasConcept C2780347916 @default.
• W2528720107 hasConcept C2780827179 @default.
• W2528720107 hasConcept C2781092963 @default.
• W2528720107 hasConcept C71924100 @default.
• W2528720107 hasConcept C86803240 @default.
• W2528720107 hasConceptScore W2528720107C118487528 @default.
• W2528720107 hasConceptScore W2528720107C169760540 @default.
• W2528720107 hasConceptScore W2528720107C178790620 @default.
• W2528720107 hasConceptScore W2528720107C185592680 @default.
• W2528720107 hasConceptScore W2528720107C2776694393 @default.
• W2528720107 hasConceptScore W2528720107C2777093970 @default.
• W2528720107 hasConceptScore W2528720107C2777100477 @default.
• W2528720107 hasConceptScore W2528720107C2778434524 @default.
• W2528720107 hasConceptScore W2528720107C2778903070 @default.
• W2528720107 hasConceptScore W2528720107C2779820397 @default.
• W2528720107 hasConceptScore W2528720107C2780347916 @default.
• W2528720107 hasConceptScore W2528720107C2780827179 @default.
• W2528720107 hasConceptScore W2528720107C2781092963 @default.

• next