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- W2528741621 abstract "Mammalian evolution has occurred in the presence of mutualistic, commensal, and pathogenic micro- and macro-organisms for millennia. The presence of these organisms during mammalian evolution has allowed for intimate crosstalk between these colonizing species and the host immune system. In this review, we introduce the concept of the 'multibiome' to holistically refer to the biodiverse collection of bacteria, viruses, fungi and multicellular helminthic worms colonizing the mammalian intestine. Furthermore, we discuss new insights into multibiome-host interactions in the context of host-protective immunity and immune-mediated diseases, including inflammatory bowel disease and multiple sclerosis. Finally, we provide reasons to account for the multibiome in experimental design, analysis and in therapeutic applications." @default.
- W2528741621 created "2016-10-14" @default.
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- W2528741621 creator A5076659584 @default.
- W2528741621 date "2016-11-01" @default.
- W2528741621 modified "2023-10-06" @default.
- W2528741621 title "The Multibiome: The Intestinal Ecosystem's Influence on Immune Homeostasis, Health, and Disease" @default.
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- W2528741621 doi "https://doi.org/10.1016/j.ebiom.2016.10.007" @default.
- W2528741621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5264270" @default.
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- W2528741621 hasPublicationYear "2016" @default.
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