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- W2528750374 abstract "Introduction The ability to sequence whole genomes at ever-increasing rates has led to the discovery of vast numbers of genes that are unique to each taxon (i.e. apomorphic genes). Before the advent of automated DNA sequencing in the early 1990s, genetic comparison of organisms was only feasible through the targeted amplification of homologous genes shared among divergent taxa, and reliable identification of taxon-specific genes was almost impossible. Shortly after the publication of the first whole genome in 1995, it became clear that species possessed many more taxonomically unique, or restricted, gene sequences than expected. When seven whole genomes had been published, R. F. Doolittle, a molecular biologist of many decades’ experience, commented: ‘I am surprised that so many open reading frames remain as unidentified [i.e. unique] reading frames’ (Doolittle 1997, p. 516). Five years later, when 60 whole genomes had been sequenced, he called taxonomically unique sequences ‘the biggest surprise in genome sequencing’ (Doolittle 2002, p. 698). Today, with whole-genome sequencing further facilitated by next generation technologies, these taxonomically restricted genes (TRGs; Khalturin et al. 2009), also known as orphan genes (Dujon 1996), or ‘ORFans’ (Fischer and Eisenberg 1999) continue to be discovered in every newly sequenced species genome (Figs 12.1 and 12.2). These genes represent one of the most intriguing aspects of systematics, lying at the intersection of genomics, genetics, comparative and structural biology, phylogenetics and evolution. Yet, by their very nature, they are difficult to study using conventional comparative approaches and attract little research funding. In this chapter, we review the current status of this conundrum in the light of rapid advances in genomics. Section 12.2 examines the definition of TRGs/ORFans, noting that this is an inherently comparative concept and the status of any gene as a TRG/ORFan is therefore highly contingent. Section 12.3 emphasizes their ubiquity. Section 12.4 discusses the biological significance of some TRGs in terms of putative functions. Section 12.5 discusses hypotheses for the origins and evolution of TRGs, and finally Section 12.6 examines the relevance of TRGs to systematics. The contingent nature of TRG classification Assigning any gene the status of ‘taxonomically restricted’ or ‘orphan’ is necessarily a relative judgement; an ‘orphan’ gene always holds its status provisionally." @default.
- W2528750374 created "2016-10-14" @default.
- W2528750374 creator A5019091797 @default.
- W2528750374 creator A5031198446 @default.
- W2528750374 date "2016-06-05" @default.
- W2528750374 modified "2023-09-23" @default.
- W2528750374 title "Next generation apomorphy: the ubiquity of taxonomically restricted genes" @default.
- W2528750374 cites W101499055 @default.
- W2528750374 cites W1519815462 @default.
- W2528750374 cites W1519987066 @default.
- W2528750374 cites W1668462635 @default.
- W2528750374 cites W1941180586 @default.
- W2528750374 cites W1965471939 @default.
- W2528750374 cites W1972894563 @default.
- W2528750374 cites W1974383394 @default.
- W2528750374 cites W1976061151 @default.
- W2528750374 cites W1978429934 @default.
- W2528750374 cites W1979552501 @default.
- W2528750374 cites W1984241784 @default.
- W2528750374 cites W1985501352 @default.
- W2528750374 cites W1986115705 @default.
- W2528750374 cites W1986356220 @default.
- W2528750374 cites W1991427331 @default.
- W2528750374 cites W1997113958 @default.
- W2528750374 cites W2003365838 @default.
- W2528750374 cites W2004778468 @default.
- W2528750374 cites W2007046901 @default.
- W2528750374 cites W2007447692 @default.
- W2528750374 cites W2009165504 @default.
- W2528750374 cites W2012750155 @default.
- W2528750374 cites W2015727531 @default.
- W2528750374 cites W2017766661 @default.
- W2528750374 cites W2019377841 @default.
- W2528750374 cites W2022709937 @default.
- W2528750374 cites W2024228623 @default.
- W2528750374 cites W2029282790 @default.
- W2528750374 cites W2033409266 @default.
- W2528750374 cites W2034365378 @default.
- W2528750374 cites W2043748606 @default.
- W2528750374 cites W2048593866 @default.
- W2528750374 cites W2050195355 @default.
- W2528750374 cites W2051418786 @default.
- W2528750374 cites W2055043387 @default.
- W2528750374 cites W2055758623 @default.
- W2528750374 cites W2055777573 @default.
- W2528750374 cites W2056200352 @default.
- W2528750374 cites W2056699111 @default.
- W2528750374 cites W2059223767 @default.
- W2528750374 cites W2059805279 @default.
- W2528750374 cites W2064620642 @default.
- W2528750374 cites W2064831300 @default.
- W2528750374 cites W2065127848 @default.
- W2528750374 cites W2071776490 @default.
- W2528750374 cites W2076849630 @default.
- W2528750374 cites W2078696465 @default.
- W2528750374 cites W2078964153 @default.
- W2528750374 cites W2079327011 @default.
- W2528750374 cites W2088201027 @default.
- W2528750374 cites W2088527057 @default.
- W2528750374 cites W2093113214 @default.
- W2528750374 cites W2093610003 @default.
- W2528750374 cites W2095829109 @default.
- W2528750374 cites W2098558111 @default.
- W2528750374 cites W2100911703 @default.
- W2528750374 cites W2101220662 @default.
- W2528750374 cites W2104690497 @default.
- W2528750374 cites W2107519392 @default.
- W2528750374 cites W2108035844 @default.
- W2528750374 cites W2108836454 @default.
- W2528750374 cites W2108923274 @default.
- W2528750374 cites W2110218196 @default.
- W2528750374 cites W2111212690 @default.
- W2528750374 cites W2114175948 @default.
- W2528750374 cites W2114746383 @default.
- W2528750374 cites W2116880153 @default.
- W2528750374 cites W2118267499 @default.
- W2528750374 cites W2120886934 @default.
- W2528750374 cites W2121534995 @default.
- W2528750374 cites W2122111434 @default.
- W2528750374 cites W2124560890 @default.
- W2528750374 cites W2127673162 @default.
- W2528750374 cites W2128643990 @default.
- W2528750374 cites W2128774397 @default.
- W2528750374 cites W2128892592 @default.
- W2528750374 cites W2129738781 @default.
- W2528750374 cites W2132706594 @default.
- W2528750374 cites W2134085791 @default.
- W2528750374 cites W2134819521 @default.
- W2528750374 cites W2134915276 @default.
- W2528750374 cites W2135123683 @default.
- W2528750374 cites W2136289616 @default.
- W2528750374 cites W2136658477 @default.
- W2528750374 cites W2136982019 @default.
- W2528750374 cites W2138024120 @default.
- W2528750374 cites W2141550398 @default.
- W2528750374 cites W2142398288 @default.
- W2528750374 cites W2142402047 @default.
- W2528750374 cites W2144752085 @default.