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• W2528754032 abstract "9 treatments for acute promyelocytic leukemia (APL) have been compared in many randomized controlled trials (RCT). The conclusions have been inconsistent and the purpose of this study is to conduct a network meta-analysis.Rankings of event-free survival are ATRA+RIF (81.2%), ATRA+ATO (69.6%), ATO (50.6%). Rankings of complete remission are ATRA+RIF (79.3%), ATRA+ATO (64.8%), RIF (60.3%), ATO (55.9%). Rankings of avoiding differentiation syndromes are CT (84.3%), ATO (80.3%), RIF (71.6%), ATRA+RIF (49%), ATRA+ATO (40.8%).A total of 1,666 patients from 12 RCTs were enrolled. The frequentist method was used. Relative risks with 95% confidence intervals were calculated. We produced a network plot, a contribution plot, and a forest plot predictive intervals. The inconsistency factor, the surface under the cumulative ranking curve and the publication bias were evaluated.ATRA+ATO is eligible to be the first-line treatment for APL. ATRA+RIF is a prospective alternative to the first-line treatment. RIF or ATO should be reconsidered as another option for de novo APL." @default.
• W2528754032 created "2016-10-14" @default.
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• W2528754032 date "2016-10-04" @default.
• W2528754032 modified "2023-09-26" @default.
• W2528754032 title "Induction treatments for acute promyelocytic leukemia: a network meta-analysis" @default.
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• W2528754032 doi "https://doi.org/10.18632/oncotarget.12451" @default.
• W2528754032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5342137" @default.
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• W2528754032 hasPublicationYear "2016" @default.
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