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- W2528758416 abstract "Anti-oxidant and heamatological indices in mice passaged with quinine resistant Plasmodium berghei treated with chloroquine co-administered with flavonoid rich anti-plasmodial fraction of Moringa oleifera leaves were determined in this study. Using Rane’s test, 60 male albino mice were randomized into 10 groups of six mice each. Nine groups were inoculated with quinine resistant strains of Plasmodium berghei and treated with tween 80, 10 mg/kg chloroquine (CQ) co-administered with graded concentrations of fractions of Moringa oleifera leaves, and standard artemisinin combination therapy (ACT) drug, Artemether lumefantrin at a dose of 1.14/6.85 mg/kg, while the uninfected Tenth Group was treated with tween 80. In addition to the parasitaemia suppression, malondialdehyde (MDA), enzymic anti-oxidant activities, non enzymic anti-oxidants concentrations and heamatological indices were determined from blood collected by ocular puncture using standard methods. Phytochemical profiling of fraction was done using standard methods. The extract co-administration with 10 mg/kg CQ significantly ( p 0.05) in the CQ-fraction treated groups when compared to the ACT treated-group. The finding of this study has demonstrated the CQ resistance reversal of extract of M. oleifera leaves with amelioration of malarial-induced haematological and oxidative stress. Keywords: resistance reversal, Moringa oleifera , co-administration, anti-oxidants" @default.
- W2528758416 created "2016-10-14" @default.
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- W2528758416 date "2016-10-03" @default.
- W2528758416 modified "2023-09-25" @default.
- W2528758416 title "Haematological and anti-oxidant changes associated with chloroquine resistance reversal by leaf extract of <i>Moringa oleifera</i> Lam" @default.
- W2528758416 doi "https://doi.org/10.4314/njpar.v37i2.13" @default.
- W2528758416 hasPublicationYear "2016" @default.
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