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• W2528766606 abstract "Odorant-binding proteins (OBPs) are of great importance for survival and reproduction since they participate in initial steps of the olfactory signal transduction cascade, solubilizing and transporting chemical signals to the olfactory receptors. A comparative analysis of OBPs between closely related species may help explain how these genes evolve and are maintained under natural selection and how differences in these proteins can affect olfactory responses. We studied OBP genes in the closely related species Anastrepha fraterculus and A. obliqua, which have different host preferences, using data from RNA-seq cDNA libraries of head and reproductive tissues from male and female adults, aiming to understand the speciation process occurred between them. We identified 23 different OBP sequences from Anastrepha fraterculus and 24 from A. obliqua, which correspond to 20 Drosophila melanogaster OBP genes. Phylogenetic analysis separated Anastrepha OBPs sequences in four branches that represent four subfamilies: classic, minus-C, plus-C and dimer. Both species showed five plus-C members, which is the biggest number found in tephritids until now. We found evidence of positive selection in four genes and at least one duplication event that preceded the speciation of these two species. Inferences on tertiary structures of putative proteins from these genes revealed that at least one positively selected change involves the binding cavity (the odorant binding region) in the plus-C OBP50a. A. fraterculus and A. obliqua have a bigger OBP repertoire than the other tephritids studied, though the total number of Anastrepha OBPs may be larger, since we studied only a limited number of tissues. The contrast of these closely related species reveals that there are several amino acid changes between the homologous genes, which might be related to their host preferences. The plus-C OBP that has one amino acid under positive selection located in the binding cavity may be under a selection pressure to recognize and bind a new odorant. The other positively selected sites found may be involved in important structural and functional changes, especially ones in which site-specific changes would radically change amino acid properties." @default.
• W2528766606 created "2016-10-14" @default.
• W2528766606 creator A5003272154 @default.
• W2528766606 creator A5003629742 @default.
• W2528766606 date "2016-10-07" @default.
• W2528766606 modified "2023-10-17" @default.
• W2528766606 title "Molecular evolution of Odorant-binding proteins gene family in two closely related Anastrepha fruit flies" @default.
• W2528766606 cites W1531319698 @default.
• W2528766606 cites W158864971 @default.
• W2528766606 cites W1919906216 @default.
• W2528766606 cites W1971260818 @default.
• W2528766606 cites W1973245739 @default.
• W2528766606 cites W1973951377 @default.
• W2528766606 cites W1974817308 @default.
• W2528766606 cites W1982274607 @default.
• W2528766606 cites W1985163355 @default.
• W2528766606 cites W1985993046 @default.
• W2528766606 cites W1987024797 @default.
• W2528766606 cites W1990938805 @default.
• W2528766606 cites W1999373399 @default.
• W2528766606 cites W2003062832 @default.
• W2528766606 cites W2004745382 @default.
• W2528766606 cites W2011091380 @default.
• W2528766606 cites W2018217912 @default.
• W2528766606 cites W2026799634 @default.
• W2528766606 cites W2029496776 @default.
• W2528766606 cites W2041258236 @default.
• W2528766606 cites W2044811358 @default.
• W2528766606 cites W2045641296 @default.
• W2528766606 cites W2045888260 @default.
• W2528766606 cites W2049174326 @default.
• W2528766606 cites W2051213056 @default.
• W2528766606 cites W2052110854 @default.
• W2528766606 cites W2054595394 @default.
• W2528766606 cites W2055043387 @default.
• W2528766606 cites W2057291233 @default.
• W2528766606 cites W2057456873 @default.
• W2528766606 cites W2060259273 @default.
• W2528766606 cites W2066221034 @default.
• W2528766606 cites W2069585323 @default.
• W2528766606 cites W2071163325 @default.
• W2528766606 cites W2074094315 @default.
• W2528766606 cites W2076946744 @default.
• W2528766606 cites W2082308131 @default.
• W2528766606 cites W2082840827 @default.
• W2528766606 cites W2088794269 @default.
• W2528766606 cites W2091181646 @default.
• W2528766606 cites W2097977090 @default.
• W2528766606 cites W2098883199 @default.
• W2528766606 cites W2099560716 @default.
• W2528766606 cites W2100895873 @default.
• W2528766606 cites W2102926253 @default.
• W2528766606 cites W2108550123 @default.
• W2528766606 cites W2108685828 @default.
• W2528766606 cites W2110335151 @default.
• W2528766606 cites W2111211467 @default.
• W2528766606 cites W2112580014 @default.
• W2528766606 cites W2118040936 @default.
• W2528766606 cites W2120611093 @default.
• W2528766606 cites W2121061454 @default.
• W2528766606 cites W2121200262 @default.
• W2528766606 cites W2125867054 @default.
• W2528766606 cites W2126419817 @default.
• W2528766606 cites W2128296317 @default.
• W2528766606 cites W2129710424 @default.
• W2528766606 cites W2131141228 @default.
• W2528766606 cites W2131893030 @default.
• W2528766606 cites W2134268801 @default.
• W2528766606 cites W2137015675 @default.
• W2528766606 cites W2140028978 @default.
• W2528766606 cites W2141008678 @default.
• W2528766606 cites W2144141060 @default.
• W2528766606 cites W2149649966 @default.
• W2528766606 cites W2151241855 @default.
• W2528766606 cites W2152828577 @default.
• W2528766606 cites W2154770881 @default.
• W2528766606 cites W2155058421 @default.
• W2528766606 cites W2157665519 @default.
• W2528766606 cites W2157688858 @default.
• W2528766606 cites W2159933033 @default.
• W2528766606 cites W2160378127 @default.
• W2528766606 cites W2161019186 @default.
• W2528766606 cites W2162143951 @default.
• W2528766606 cites W2165892911 @default.
• W2528766606 cites W2167133711 @default.
• W2528766606 cites W2171022989 @default.
• W2528766606 cites W2172005807 @default.
• W2528766606 cites W2216143568 @default.
• W2528766606 cites W2329809450 @default.
• W2528766606 cites W2507670212 @default.
• W2528766606 cites W54608552 @default.
• W2528766606 doi "https://doi.org/10.1186/s12862-016-0775-0" @default.
• W2528766606 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5054612" @default.
• W2528766606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27716035" @default.
• W2528766606 hasPublicationYear "2016" @default.
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