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- W2528828967 abstract "The nonstructural protein 1α (NSP1α) of porcine reproductive and respiratory syndrome virus (PRRSV) is a nucleo-cytoplasmic protein that suppresses the production of type I interferon (IFN). In this study, we investigated the relationship between the subcellular distribution of NSP1α and its inhibition of type I IFN. NSP1α was found to contain the classical nuclear export signal (NES) and NSP1α nuclear export was CRM-1-mediated. NSP1α was shuttling between the nucleus and cytoplasm. We also showed that the nuclear export of NSP1α was necessary for its ability for type I IFN inhibition. NSP1α was also found to interact with CBP, which implies a possible mechanism of CBP degradation by NSP1α. Taken together, our results describe a novel mechanism of PRRSV NSP1α for type I IFN inhibition and suppression of the host innate antiviral response. • NSP1α contains the NES and NSP1α nuclear export was CRM-1-mediated. • NSP1α was shuttling between the nucleus and cytoplasm continuously. • The nuclear export of NSP1α was necessary for its ability for type I IFN inhibition. • NSP1α interacts with CBP, which implies the mechanism of CBP degradation by NSP1α." @default.
- W2528828967 created "2016-10-14" @default.
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- W2528828967 date "2016-12-01" @default.
- W2528828967 modified "2023-10-12" @default.
- W2528828967 title "Nuclear export signal of PRRSV NSP1α is necessary for type I IFN inhibition" @default.
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- W2528828967 cites W1997840906 @default.
- W2528828967 cites W1998007178 @default.
- W2528828967 cites W2000543657 @default.
- W2528828967 cites W2001584156 @default.
- W2528828967 cites W2003326274 @default.
- W2528828967 cites W2003847336 @default.
- W2528828967 cites W2008099851 @default.
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- W2528828967 doi "https://doi.org/10.1016/j.virol.2016.07.008" @default.
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