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- W2528851578 abstract "Purpose: The purpose of this study is to evaluate the contribution, efficacy and safety of preemptive intravenous lornoxicam 8 mg on postoperative analgesia in patients who shall undergo spinal surgery and instrumentation.Materials and Methods: 50 adult (18-65) patients from ASA I-II risk group, scheduled for elective spinal surgery were included in clinical prospective, randomized, double blind, placebo controlled study. Lornoxicam 8 mg (in 100 ml physiological serum iv) was administered to the first group (Group L; n=25) and 100 ml physiological serum iv was administered by perfusor to the second group (Group P; n=25) 30 minutes before surgical incision. General anesthesia was applied after standard monitorization. Postoperative analgesia was performed with tramadol (iv) in 2 mg/ml concentration via patient controlled analgesia (PCA); bolus: 20 mg, lock time: 60 minutes and application time: 24 hours. Numerical Rating Scale (NRS) (0-10 points), tramadol used by PCA, frequency of drug request, additional analgesic amount consumed and effective analgesia times were recorded at the end of operation, 2nd, 4th, 6th, 12th and 24th hours.Results: Total PCA tramadol consumption during 24 hours period and frequency of PCA drug request at the end of operation, 2nd and 12th hours was significantly lower than the values for placebo (p<0.05). Total additional analgesic consumption was significantly lower when compared with placebo during the follow up period of 24 hours (p<0,05). Effective analgesia time was long in Group L (p<0,05).Conclusion: It was shown that administration of preemptive intravenous lornoxicam 8 mg for pain treatment in patients subjected to spinal surgery, decreased tramadol amount and additional analgesic amount consumed, enhanced quality of analgesia and elongated effective analgesia time." @default.
- W2528851578 created "2016-10-14" @default.
- W2528851578 creator A5076721712 @default.
- W2528851578 date "2016-08-05" @default.
- W2528851578 modified "2023-10-18" @default.
- W2528851578 title "The Contribution of Preemptive Lornoxicam on Postoperative Analgesia in Spinal Surgery" @default.
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- W2528851578 doi "https://doi.org/10.15406/jaccoa.2016.05.00191" @default.
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