Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528857537> ?p ?o ?g. }
- W2528857537 abstract "The TOR and Insulin/IGF signalling (IIS) network controls growth, metabolism and ageing. Although reducing TOR or insulin signalling can be beneficial for ageing, it can be detrimental for wound healing, but the reasons for this difference are unknown. Here we show that IIS is activated in the cells surrounding an epidermal wound in Drosophila melanogaster larvae, resulting in PI3K activation and redistribution of the transcription factor FOXO. Insulin and TOR signalling are independently necessary for normal wound healing, with FOXO and S6K as their respective effectors. IIS is specifically required in cells surrounding the wound, and the effect is independent of glycogen metabolism. Insulin signalling is needed for the efficient assembly of an actomyosin cable around the wound, and constitutively active myosin II regulatory light chain suppresses the effects of reduced IIS. These findings may have implications for the role of insulin signalling and FOXO activation in diabetic wound healing." @default.
- W2528857537 created "2016-10-14" @default.
- W2528857537 creator A5012787334 @default.
- W2528857537 creator A5054480882 @default.
- W2528857537 creator A5056190515 @default.
- W2528857537 creator A5059311261 @default.
- W2528857537 creator A5059968730 @default.
- W2528857537 creator A5083476093 @default.
- W2528857537 creator A5090932782 @default.
- W2528857537 date "2016-10-07" @default.
- W2528857537 modified "2023-10-14" @default.
- W2528857537 title "Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing" @default.
- W2528857537 cites W12591472 @default.
- W2528857537 cites W1508829110 @default.
- W2528857537 cites W1562647613 @default.
- W2528857537 cites W1579748532 @default.
- W2528857537 cites W1828486192 @default.
- W2528857537 cites W1939431494 @default.
- W2528857537 cites W1967582843 @default.
- W2528857537 cites W1967595340 @default.
- W2528857537 cites W1971964944 @default.
- W2528857537 cites W1972159966 @default.
- W2528857537 cites W1975053800 @default.
- W2528857537 cites W1987817703 @default.
- W2528857537 cites W1989363737 @default.
- W2528857537 cites W1992532837 @default.
- W2528857537 cites W1994521849 @default.
- W2528857537 cites W1997227467 @default.
- W2528857537 cites W2002356275 @default.
- W2528857537 cites W2003352911 @default.
- W2528857537 cites W2006943746 @default.
- W2528857537 cites W2009607823 @default.
- W2528857537 cites W2010583480 @default.
- W2528857537 cites W2012569825 @default.
- W2528857537 cites W2022158972 @default.
- W2528857537 cites W2024631862 @default.
- W2528857537 cites W2024816720 @default.
- W2528857537 cites W2029478181 @default.
- W2528857537 cites W2030700131 @default.
- W2528857537 cites W2040377035 @default.
- W2528857537 cites W2052112605 @default.
- W2528857537 cites W2052190647 @default.
- W2528857537 cites W2054815464 @default.
- W2528857537 cites W2055375964 @default.
- W2528857537 cites W2055893161 @default.
- W2528857537 cites W2056388945 @default.
- W2528857537 cites W2058397178 @default.
- W2528857537 cites W2059135549 @default.
- W2528857537 cites W2066706221 @default.
- W2528857537 cites W2069619727 @default.
- W2528857537 cites W2073006837 @default.
- W2528857537 cites W2076691009 @default.
- W2528857537 cites W2079505765 @default.
- W2528857537 cites W2080413184 @default.
- W2528857537 cites W2082088742 @default.
- W2528857537 cites W2083794211 @default.
- W2528857537 cites W2088782756 @default.
- W2528857537 cites W2092213819 @default.
- W2528857537 cites W2093858064 @default.
- W2528857537 cites W2097068323 @default.
- W2528857537 cites W2099677820 @default.
- W2528857537 cites W2110643873 @default.
- W2528857537 cites W2114644968 @default.
- W2528857537 cites W2125545718 @default.
- W2528857537 cites W2126774045 @default.
- W2528857537 cites W2127903487 @default.
- W2528857537 cites W2128655116 @default.
- W2528857537 cites W2129322966 @default.
- W2528857537 cites W2129618055 @default.
- W2528857537 cites W2130095246 @default.
- W2528857537 cites W2132752000 @default.
- W2528857537 cites W2139151825 @default.
- W2528857537 cites W2157725915 @default.
- W2528857537 cites W2160933802 @default.
- W2528857537 cites W2161007406 @default.
- W2528857537 cites W2163093080 @default.
- W2528857537 cites W2163211683 @default.
- W2528857537 cites W2164438840 @default.
- W2528857537 cites W2165599246 @default.
- W2528857537 cites W2181024941 @default.
- W2528857537 cites W2764507256 @default.
- W2528857537 cites W3134167119 @default.
- W2528857537 doi "https://doi.org/10.1038/ncomms12972" @default.
- W2528857537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5059774" @default.
- W2528857537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27713427" @default.
- W2528857537 hasPublicationYear "2016" @default.
- W2528857537 type Work @default.
- W2528857537 sameAs 2528857537 @default.
- W2528857537 citedByCount "46" @default.
- W2528857537 countsByYear W25288575372017 @default.
- W2528857537 countsByYear W25288575372018 @default.
- W2528857537 countsByYear W25288575372019 @default.
- W2528857537 countsByYear W25288575372020 @default.
- W2528857537 countsByYear W25288575372021 @default.
- W2528857537 countsByYear W25288575372022 @default.
- W2528857537 countsByYear W25288575372023 @default.
- W2528857537 crossrefType "journal-article" @default.
- W2528857537 hasAuthorship W2528857537A5012787334 @default.
- W2528857537 hasAuthorship W2528857537A5054480882 @default.
- W2528857537 hasAuthorship W2528857537A5056190515 @default.