Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528939866> ?p ?o ?g. }
- W2528939866 endingPage "1531" @default.
- W2528939866 startingPage "1516" @default.
- W2528939866 abstract "Historically, cancers have been treated with chemotherapeutics aimed to have profound effects on tumor cells with only limited effects on normal tissue. This approach was followed by the development of small-molecule inhibitors that can target oncogenic pathways critical for the survival of tumor cells. The clinical targeting of these so-called oncogene addictions, however, is in many instances hampered by the outgrowth of resistant clones. More recently, the proper functioning of non-mutated genes has been shown to enhance the survival of many cancers, a phenomenon called non-oncogene addiction. In the current review, we will focus on the distinct non-oncogenic addictions found in cancer cells, including synthetic lethal interactions, the underlying stress phenotypes, and arising therapeutic opportunities." @default.
- W2528939866 created "2016-10-14" @default.
- W2528939866 creator A5028292731 @default.
- W2528939866 creator A5028894540 @default.
- W2528939866 creator A5035790268 @default.
- W2528939866 date "2016-10-04" @default.
- W2528939866 modified "2023-10-18" @default.
- W2528939866 title "Drugging the addict: non‐oncogene addiction as a target for cancer therapy" @default.
- W2528939866 cites W1263857580 @default.
- W2528939866 cites W1414516785 @default.
- W2528939866 cites W1534516194 @default.
- W2528939866 cites W1541421641 @default.
- W2528939866 cites W1562068210 @default.
- W2528939866 cites W1583557220 @default.
- W2528939866 cites W1657803481 @default.
- W2528939866 cites W1882824745 @default.
- W2528939866 cites W1923410233 @default.
- W2528939866 cites W1940455180 @default.
- W2528939866 cites W1963759286 @default.
- W2528939866 cites W1964353872 @default.
- W2528939866 cites W1964661396 @default.
- W2528939866 cites W1965009601 @default.
- W2528939866 cites W1965080968 @default.
- W2528939866 cites W1965223939 @default.
- W2528939866 cites W1965316429 @default.
- W2528939866 cites W1966826063 @default.
- W2528939866 cites W1967736480 @default.
- W2528939866 cites W1971617980 @default.
- W2528939866 cites W1972215727 @default.
- W2528939866 cites W1973268287 @default.
- W2528939866 cites W1974546855 @default.
- W2528939866 cites W1974771871 @default.
- W2528939866 cites W1976495381 @default.
- W2528939866 cites W1977431691 @default.
- W2528939866 cites W1980097907 @default.
- W2528939866 cites W1980181091 @default.
- W2528939866 cites W1981258651 @default.
- W2528939866 cites W1982114544 @default.
- W2528939866 cites W1983623192 @default.
- W2528939866 cites W1985318741 @default.
- W2528939866 cites W1986076152 @default.
- W2528939866 cites W1987344383 @default.
- W2528939866 cites W1987604182 @default.
- W2528939866 cites W1988609792 @default.
- W2528939866 cites W1988811375 @default.
- W2528939866 cites W1989139022 @default.
- W2528939866 cites W1989829388 @default.
- W2528939866 cites W1991199800 @default.
- W2528939866 cites W1993238109 @default.
- W2528939866 cites W1993475190 @default.
- W2528939866 cites W1997324813 @default.
- W2528939866 cites W1998560601 @default.
- W2528939866 cites W1999402226 @default.
- W2528939866 cites W2001569984 @default.
- W2528939866 cites W2004142027 @default.
- W2528939866 cites W2006141070 @default.
- W2528939866 cites W2008306394 @default.
- W2528939866 cites W2009931781 @default.
- W2528939866 cites W2010023860 @default.
- W2528939866 cites W2010161828 @default.
- W2528939866 cites W2011401291 @default.
- W2528939866 cites W2012053348 @default.
- W2528939866 cites W2013152912 @default.
- W2528939866 cites W2013747211 @default.
- W2528939866 cites W2014097228 @default.
- W2528939866 cites W2014624348 @default.
- W2528939866 cites W2014988241 @default.
- W2528939866 cites W2017289276 @default.
- W2528939866 cites W2017433159 @default.
- W2528939866 cites W2017558556 @default.
- W2528939866 cites W2019156893 @default.
- W2528939866 cites W2021437940 @default.
- W2528939866 cites W2021699091 @default.
- W2528939866 cites W2022531767 @default.
- W2528939866 cites W2022899908 @default.
- W2528939866 cites W2024889065 @default.
- W2528939866 cites W2025618547 @default.
- W2528939866 cites W2029000257 @default.
- W2528939866 cites W2030057907 @default.
- W2528939866 cites W2031793125 @default.
- W2528939866 cites W2032685334 @default.
- W2528939866 cites W2033496263 @default.
- W2528939866 cites W2033901119 @default.
- W2528939866 cites W2036072875 @default.
- W2528939866 cites W2036307706 @default.
- W2528939866 cites W2037313242 @default.
- W2528939866 cites W2037338364 @default.
- W2528939866 cites W2038212896 @default.
- W2528939866 cites W2038798987 @default.
- W2528939866 cites W2039312402 @default.
- W2528939866 cites W2040154374 @default.
- W2528939866 cites W2043696829 @default.
- W2528939866 cites W2044798778 @default.
- W2528939866 cites W2047990847 @default.
- W2528939866 cites W2049524122 @default.
- W2528939866 cites W2052085642 @default.
- W2528939866 cites W2052540412 @default.
- W2528939866 cites W2053950888 @default.