FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2528989516> ?p ?o ?g. }

• W2528989516 endingPage "8" @default.
• W2528989516 startingPage "1" @default.
• W2528989516 abstract "Aims To determine the predictive utility of polygenic risk scores of common variants associated with type 2 diabetes derived from the European and Asian ethnicities among a black South African population. Method Our study was a case-control study nested within the Prospective Urban and Rural Epidemiological (PURE) study of 178 male and female cases, matched for age and gender with 178 controls. Four types of genetic risk scores (GRS) were developed from 66 selected SNPs. These comprised of beta cell related variants (GRSb), variants which had significant associations with T2D in our study (GRSn), variants from the trans-ethnic meta-analysis (GRStrans) and all the 66 selected SNPs (GRSt). Results Of the GRS’s, only GRSn was associated with increased risk of T2D as indicated by an OR (95CI) of 1.21 (1.02–1.43) p-value = 0.015. Stratified analysis of age and BMI, indicated the GRSn to be significantly associated with T2D among the non-obese and participants less than 50 years. The area under the ROC of the T2D risk factors only was 0.652 (p value < 0.001) and with the addition of GRSn it was 0.665 (p value < 0.001). Conclusions The GRS of European and Asian derived variants have limited clinical utility in the black South African population. The inclusion of population specific variants in the GRS is pivotal." @default.
• W2528989516 created "2016-10-14" @default.
• W2528989516 creator A5011637707 @default.
• W2528989516 creator A5058855272 @default.
• W2528989516 creator A5084847544 @default.
• W2528989516 creator A5091567665 @default.
• W2528989516 date "2016-12-01" @default.
• W2528989516 modified "2023-09-23" @default.
• W2528989516 title "Predictive utility of a genetic risk score of common variants associated with type 2 diabetes in a black South African population" @default.
• W2528989516 cites W1787521811 @default.
• W2528989516 cites W1855576760 @default.
• W2528989516 cites W1919620167 @default.
• W2528989516 cites W1944558458 @default.
• W2528989516 cites W1966254895 @default.
• W2528989516 cites W1973662650 @default.
• W2528989516 cites W1978215768 @default.
• W2528989516 cites W1983425639 @default.
• W2528989516 cites W1984003932 @default.
• W2528989516 cites W1989970381 @default.
• W2528989516 cites W2004336671 @default.
• W2528989516 cites W2009020864 @default.
• W2528989516 cites W2024546585 @default.
• W2528989516 cites W2025086473 @default.
• W2528989516 cites W2028941345 @default.
• W2528989516 cites W2044518560 @default.
• W2528989516 cites W2045017910 @default.
• W2528989516 cites W2046952982 @default.
• W2528989516 cites W2048755332 @default.
• W2528989516 cites W2070665653 @default.
• W2528989516 cites W2082122713 @default.
• W2528989516 cites W2086989226 @default.
• W2528989516 cites W2088397492 @default.
• W2528989516 cites W2093011816 @default.
• W2528989516 cites W2097843904 @default.
• W2528989516 cites W2112070944 @default.
• W2528989516 cites W2112869109 @default.
• W2528989516 cites W2117238405 @default.
• W2528989516 cites W2126100846 @default.
• W2528989516 cites W2141642891 @default.
• W2528989516 cites W2141770478 @default.
• W2528989516 cites W2145604455 @default.
• W2528989516 cites W2146264121 @default.
• W2528989516 cites W2148749248 @default.
• W2528989516 cites W2160115185 @default.
• W2528989516 cites W2161261572 @default.
• W2528989516 cites W2161287598 @default.
• W2528989516 cites W2161633633 @default.
• W2528989516 cites W2168825241 @default.
• W2528989516 cites W2169189827 @default.
• W2528989516 cites W2170801801 @default.
• W2528989516 cites W2182386336 @default.
• W2528989516 cites W2183780835 @default.
• W2528989516 cites W2219885223 @default.
• W2528989516 cites W2257024835 @default.
• W2528989516 cites W2464875409 @default.
• W2528989516 cites W328199783 @default.
• W2528989516 cites W335305751 @default.
• W2528989516 cites W348880069 @default.
• W2528989516 cites W4210953420 @default.
• W2528989516 cites W746631390 @default.
• W2528989516 doi "https://doi.org/10.1016/j.diabres.2016.09.019" @default.
• W2528989516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27744072" @default.
• W2528989516 hasPublicationYear "2016" @default.
• W2528989516 type Work @default.
• W2528989516 sameAs 2528989516 @default.
• W2528989516 citedByCount "16" @default.
• W2528989516 countsByYear W25289895162017 @default.
• W2528989516 countsByYear W25289895162019 @default.
• W2528989516 countsByYear W25289895162020 @default.
• W2528989516 countsByYear W25289895162021 @default.
• W2528989516 countsByYear W25289895162022 @default.
• W2528989516 countsByYear W25289895162023 @default.
• W2528989516 crossrefType "journal-article" @default.
• W2528989516 hasAuthorship W2528989516A5011637707 @default.
• W2528989516 hasAuthorship W2528989516A5058855272 @default.
• W2528989516 hasAuthorship W2528989516A5084847544 @default.
• W2528989516 hasAuthorship W2528989516A5091567665 @default.
• W2528989516 hasConcept C104317684 @default.
• W2528989516 hasConcept C107130276 @default.
• W2528989516 hasConcept C126322002 @default.
• W2528989516 hasConcept C134018914 @default.
• W2528989516 hasConcept C135763542 @default.
• W2528989516 hasConcept C137403100 @default.
• W2528989516 hasConcept C144024400 @default.
• W2528989516 hasConcept C149923435 @default.
• W2528989516 hasConcept C153209595 @default.
• W2528989516 hasConcept C19165224 @default.
• W2528989516 hasConcept C2777180221 @default.
• W2528989516 hasConcept C2908647359 @default.
• W2528989516 hasConcept C54355233 @default.
• W2528989516 hasConcept C555293320 @default.
• W2528989516 hasConcept C71924100 @default.
• W2528989516 hasConcept C86803240 @default.
• W2528989516 hasConcept C99454951 @default.
• W2528989516 hasConceptScore W2528989516C104317684 @default.
• W2528989516 hasConceptScore W2528989516C107130276 @default.
• W2528989516 hasConceptScore W2528989516C126322002 @default.
• W2528989516 hasConceptScore W2528989516C134018914 @default.

• next