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- W2529121136 abstract "Erythropoietin (EPO) was first identified as a regulator of erythropoiesis. Additional studies have demonstrated a myriad of pleotropic effects (eg, an ability to decrease inflammation, oxidative stress, and apoptosis). Further, EPO facilitates both angiogenesis and neurogenesis and modulates core components of primary and secondary brain injury. Animal models have confirmed the therapeutic potential of EPO in both experimental ischemic and traumatic brain injury (TBI). Unfortunately, clinical studies in stroke, TBI, and other related neurological injuries/disorders have thus far failed to demonstrate meaningful improvements after interventions with EPO. The surprising failure of EPO in clinical trials may be linked to inadequate dosing regimens, incorrect timing of treatments, duration of the therapy, and/or to inability (eg, lack of sensitivity) to detect outcomes reflective of clinical improvement. As such, optimized administration of EPO or EPO derivatives may provide a novel therapeutic approach for treatment of currently intractable brain injuries and illnesses." @default.
- W2529121136 created "2016-10-14" @default.
- W2529121136 creator A5005597929 @default.
- W2529121136 creator A5007090414 @default.
- W2529121136 creator A5029617270 @default.
- W2529121136 creator A5044763521 @default.
- W2529121136 creator A5056323628 @default.
- W2529121136 date "2017-01-01" @default.
- W2529121136 modified "2023-10-17" @default.
- W2529121136 title "Erythropoietin and Its Derivatives" @default.
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