FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2529121786> ?p ?o ?g. }

• W2529121786 abstract "There is a need to identify individuals with COPD at risk for disease progression and mortality. Lung tissue remodeling is associated with the release of extracellular matrix (ECM) fragments into the peripheral circulation. We hypothesized that ECM remodeling was associated with mortality in COPD and measured neo-epitopes originating from ECM proteins associated with lung tissue remodeling. Biomarkers of ECM remodeling were assessed in a subpopulation (n = 1000) of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) cohort. Validated immunoassays measuring serological neo-epitopes produced by proteolytic cleavage associated with degradation of collagen type I, III, IV, and VI, elastin, and biglycan, and formation of collagen type VI as well as fibrinogen and C-reactive protein were used. Multivariate models were used to assess the prognostic value of these biomarkers. Thirty subjects (3.0 %) died during follow-up. Non-survivors were older, had reduced exercise capacity, increased dyspnea score, and included fewer current smokers. All collagen biomarkers were significantly elevated in non-survivors compared to survivors. Mortality risk was significantly increased for subjects with collagen remodeling biomarkers in the upper quartile, especially for the degradation fragment of collagen type IV C6M (hazard ratio 6.6 [95 % confidence interval 2.9-15.2], P < 0.0001) after adjusting for relevant confounders. Serological biomarkers of collagen remodeling were strongly associated with mortality in subjects with COPD indicating that assessment of tissue turnover in the parenchyma and small airways may be useful in the prognosis of COPD. NCT00292552 , GSK Study No. SCO104960." @default.
• W2529121786 created "2016-10-14" @default.
• W2529121786 creator A5003111166 @default.
• W2529121786 creator A5011776152 @default.
• W2529121786 creator A5037747729 @default.
• W2529121786 creator A5046940384 @default.
• W2529121786 creator A5054029103 @default.
• W2529121786 creator A5062465642 @default.
• W2529121786 creator A5062569126 @default.
• W2529121786 creator A5076601121 @default.
• W2529121786 creator A5083312029 @default.
• W2529121786 date "2016-10-04" @default.
• W2529121786 modified "2023-10-16" @default.
• W2529121786 title "High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD – results from the ECLIPSE study" @default.
• W2529121786 cites W1221909616 @default.
• W2529121786 cites W149149434 @default.
• W2529121786 cites W1586233199 @default.
• W2529121786 cites W1971485286 @default.
• W2529121786 cites W1973087217 @default.
• W2529121786 cites W1980474802 @default.
• W2529121786 cites W1994863837 @default.
• W2529121786 cites W2002587076 @default.
• W2529121786 cites W2003652844 @default.
• W2529121786 cites W2019173199 @default.
• W2529121786 cites W2030993607 @default.
• W2529121786 cites W2037049861 @default.
• W2529121786 cites W2042258234 @default.
• W2529121786 cites W2044245090 @default.
• W2529121786 cites W2046246972 @default.
• W2529121786 cites W2056875960 @default.
• W2529121786 cites W2065752901 @default.
• W2529121786 cites W2069533740 @default.
• W2529121786 cites W2079441054 @default.
• W2529121786 cites W2082342249 @default.
• W2529121786 cites W2090530997 @default.
• W2529121786 cites W2094874764 @default.
• W2529121786 cites W2106394177 @default.
• W2529121786 cites W2112162293 @default.
• W2529121786 cites W2116784557 @default.
• W2529121786 cites W2121676520 @default.
• W2529121786 cites W2122309353 @default.
• W2529121786 cites W2122485317 @default.
• W2529121786 cites W2122590281 @default.
• W2529121786 cites W2125065061 @default.
• W2529121786 cites W2133863770 @default.
• W2529121786 cites W2135939624 @default.
• W2529121786 cites W2136037247 @default.
• W2529121786 cites W2139347600 @default.
• W2529121786 cites W2142096203 @default.
• W2529121786 cites W2142250980 @default.
• W2529121786 cites W2145900171 @default.
• W2529121786 cites W2147495597 @default.
• W2529121786 cites W2154204110 @default.
• W2529121786 cites W2159488456 @default.
• W2529121786 cites W2172592858 @default.
• W2529121786 cites W2195607455 @default.
• W2529121786 cites W2328176404 @default.
• W2529121786 cites W39967193 @default.
• W2529121786 cites W774234807 @default.
• W2529121786 doi "https://doi.org/10.1186/s12931-016-0440-6" @default.
• W2529121786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5050854" @default.
• W2529121786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27716343" @default.
• W2529121786 hasPublicationYear "2016" @default.
• W2529121786 type Work @default.
• W2529121786 sameAs 2529121786 @default.
• W2529121786 citedByCount "50" @default.
• W2529121786 countsByYear W25291217862017 @default.
• W2529121786 countsByYear W25291217862018 @default.
• W2529121786 countsByYear W25291217862019 @default.
• W2529121786 countsByYear W25291217862020 @default.
• W2529121786 countsByYear W25291217862021 @default.
• W2529121786 countsByYear W25291217862022 @default.
• W2529121786 countsByYear W25291217862023 @default.
• W2529121786 crossrefType "journal-article" @default.
• W2529121786 hasAuthorship W2529121786A5003111166 @default.
• W2529121786 hasAuthorship W2529121786A5011776152 @default.
• W2529121786 hasAuthorship W2529121786A5037747729 @default.
• W2529121786 hasAuthorship W2529121786A5046940384 @default.
• W2529121786 hasAuthorship W2529121786A5054029103 @default.
• W2529121786 hasAuthorship W2529121786A5062465642 @default.
• W2529121786 hasAuthorship W2529121786A5062569126 @default.
• W2529121786 hasAuthorship W2529121786A5076601121 @default.
• W2529121786 hasAuthorship W2529121786A5083312029 @default.
• W2529121786 hasBestOaLocation W25291217861 @default.
• W2529121786 hasConcept C126322002 @default.
• W2529121786 hasConcept C142724271 @default.
• W2529121786 hasConcept C189165786 @default.
• W2529121786 hasConcept C203014093 @default.
• W2529121786 hasConcept C207103383 @default.
• W2529121786 hasConcept C2776780178 @default.
• W2529121786 hasConcept C2777910003 @default.
• W2529121786 hasConcept C2781197716 @default.
• W2529121786 hasConcept C44249647 @default.
• W2529121786 hasConcept C50382708 @default.
• W2529121786 hasConcept C55493867 @default.
• W2529121786 hasConcept C71924100 @default.
• W2529121786 hasConcept C86803240 @default.
• W2529121786 hasConcept C90924648 @default.
• W2529121786 hasConcept C95444343 @default.
• W2529121786 hasConceptScore W2529121786C126322002 @default.

• next