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- W2529122827 endingPage "577" @default.
- W2529122827 startingPage "557" @default.
- W2529122827 abstract "The genetic code—the language used by cells to translate their genomes into proteins that perform many cellular functions—is highly conserved throughout natural life. Rewriting the genetic code could lead to new biological functions such as expanding protein chemistries with noncanonical amino acids (ncAAs) and genetically isolating synthetic organisms from natural organisms and viruses. It has long been possible to transiently produce proteins bearing ncAAs, but stabilizing an expanded genetic code for sustained function in vivo requires an integrated approach: creating recoded genomes and introducing new translation machinery that function together without compromising viability or clashing with endogenous pathways. In this review, we discuss design considerations and technologies for expanding the genetic code. The knowledge obtained by rewriting the genetic code will deepen our understanding of how genomes are designed and how the canonical genetic code evolved." @default.
- W2529122827 created "2016-10-14" @default.
- W2529122827 creator A5033720199 @default.
- W2529122827 creator A5063450287 @default.
- W2529122827 creator A5071993338 @default.
- W2529122827 creator A5088542074 @default.
- W2529122827 date "2017-09-08" @default.
- W2529122827 modified "2023-09-30" @default.
- W2529122827 title "Rewriting the Genetic Code" @default.
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