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• W2529125088 abstract "Abstract Nicotine decreases food intake, and smokers often report that they smoke to control their weight. To see whether similar phenomena could be observed in the model organism Caenorhabditis elegans , we challenged drug-naïve nematodes with a chronic low (0.01 mM) and high (1 mM) nicotine concentration for 55 h (from hatching to adulthood). After that, we recorded changes in their behavior in a nicotine gradient, where they could choose a desired nicotine concentration. By using a combination of behavioral and morphometric methods, we found that both nicotine and food modulate worm behavior. In the presence of food the nematodes adapted to the low nicotine concentration, when placed in the gradient, chose a similar nicotine concentration like C. elegans adapted to the high nicotine concentration. However, in the absence of food, the nematodes adapted to the low nicotine concentration, when placed in the gradient of this alkaloid, chose a similar nicotine concentration like naïve worms. The nematodes growing up in the presence of high concentrations of nicotine had a statistically smaller body size, compared to the control condition, and the presence of food did not cause any enhanced slowing movement. These results provide a platform for more detailed molecular and cellular studies of nicotine addiction and food intake in this model organism." @default.
• W2529125088 created "2016-10-14" @default.
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• W2529125088 date "2016-10-07" @default.
• W2529125088 modified "2023-09-26" @default.
• W2529125088 title "Behavior of Caenorhabditis elegans in a nicotine gradient modulated by food" @default.
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• W2529125088 doi "https://doi.org/10.1101/079699" @default.
• W2529125088 hasPublicationYear "2016" @default.
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