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- W2529188722 abstract "Irradiation of the inverted membrane vesicles of Mycobacterium phlei with light at 360 nm inactivated the coupling agents. The magnitude of the pH gradient and mem- brane potential in the quinone-restored system was a reflection of the rate of oxidation and was correlated with the rate of up- take of proline or Ca2+. These results are consistent with the chemosmotic hypothesis proposed for the energy transducing mechanism for active transport and further demonstrate that the complete respiratory chain is not required to drive active transport. In contrast, the data suggest that in addition to the driving force (protonmotive force) necessary to establish oxi- dative phosphorylation, a specific spatial orientation of the respiratory components, such as the naphthaquinones, is es- sential for the utilization of the proton gradient or membrane potential or both. Bypass of electrons from the respiratory chain with menadione may explain the inability of this quinone to restore oxidative phosphorylation; however, lapachol restores oxidation by the same electron transport pathway as the natural menaquinone but fails to restore phosphorylation. Because all three quinones restore the protonmotive force, other factors that are discussed must be considered in understanding the mech- anism of oxidative phosphorylation. quinone or vitamin K1; (ii) restoration of only oxidation, by the same electron transport pathway as that observed with the natural quinone, by quinones such as lapachol (2-hydroxyl- 3-(3-methyl-2-butenyl-1,4-naphthoquinone)) or dihydrophytyl vitamin K1; and (iii) restoration of oxidation by bypassing a segment of the electron transport pathway or by reacting directly with oxygen, by quinones such as menadione (2- methyl-1,4-naphthoquinone) or 2-methoxy-1,4-napthoqui- none. In contrast to oxidative phosphorylation, active transport of solutes can be driven by menadione, lapachol, or artificial" @default.
- W2529188722 created "2016-10-14" @default.
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- W2529188722 date "2016-01-01" @default.
- W2529188722 modified "2023-10-06" @default.
- W2529188722 title "Restoration of active transport of solutes and oxidative phosphorylation by naphthoquinones in irradiated membrane vesicles from Mycobacterium phlei (UV irradiation/specificity of naphthoquinones/protonmotive force/proline and calcium transport)" @default.
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