Matches in SemOpenAlex for { <https://semopenalex.org/work/W2529200090> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2529200090 endingPage "451" @default.
- W2529200090 startingPage "443" @default.
- W2529200090 abstract "Mesalamine (5-ASA) is one of the drugs indicated as first line therapy in ulcerative colitis for induction and maintenance of remission. Sulfasalazine and formulations of 5-ASA (pH-dependent and controlled release formulations) were developed to minimize the systemic absorption and maximize the delivery of the mesalamine to colon. Although, its efficacy and safety is well documented there are approximately 30% nonresponders to 5-ASA therapy. This necessitates the need for novel therapeutic options to improve the efficacy and safety of the currently available 5-ASA therapy. CLX-103 is a novel, patented prodrug molecular conjugate of mesalamine, eicosapentaenoic acid and caprylic acid designed to offer incremental benefits over the currently approved 5-ASA formulations. Results of in vitro and in vivo studies showed that CLX-103, was stable in simulated gastric fluid, but undergoes enzymatic hydrolysis in the small/large intestines to release the active moiety. Our data also showed that the active moiety is retained in the targeted intestinal tissues (ileum and colon) over a longer period of time in relation to sulfasalazine. The in vitro data supports the observed in vivo plasma kinetics of 5-ASA characterized by longer Tmax, low Cmax after the oral administration of CLX-103. Efficacy study of CLX-103 in acute dextran sodium sulfate (DSS) mouse colitis model showed improved potency measured as Disease Activity Index (DAI) and histological scores in the colon as compared to sulfasalazine. These findings indicate that CLX-103 could offer a differentiated drug product which is more efficacious and safer than the currently approved 5-ASA formulations in the treatment of inflammatory bowel diseases." @default.
- W2529200090 created "2016-10-14" @default.
- W2529200090 creator A5008439349 @default.
- W2529200090 creator A5019072217 @default.
- W2529200090 creator A5047834392 @default.
- W2529200090 creator A5081701920 @default.
- W2529200090 date "2016-11-01" @default.
- W2529200090 modified "2023-10-13" @default.
- W2529200090 title "Discovery and preclinical development of a novel prodrug conjugate of mesalamine with eicosapentaenoic acid and caprylic acid for the treatment of inflammatory bowel diseases" @default.
- W2529200090 cites W1596389679 @default.
- W2529200090 cites W1930299866 @default.
- W2529200090 cites W1959828319 @default.
- W2529200090 cites W1973326673 @default.
- W2529200090 cites W1974340449 @default.
- W2529200090 cites W1974720245 @default.
- W2529200090 cites W1984426896 @default.
- W2529200090 cites W2004313032 @default.
- W2529200090 cites W2005714706 @default.
- W2529200090 cites W2007305945 @default.
- W2529200090 cites W2011135579 @default.
- W2529200090 cites W2011556145 @default.
- W2529200090 cites W2047852273 @default.
- W2529200090 cites W2062854941 @default.
- W2529200090 cites W2072186197 @default.
- W2529200090 cites W2078326202 @default.
- W2529200090 cites W2083733411 @default.
- W2529200090 cites W2087676567 @default.
- W2529200090 cites W2151100255 @default.
- W2529200090 cites W2154313239 @default.
- W2529200090 cites W2154479392 @default.
- W2529200090 cites W2156345493 @default.
- W2529200090 cites W2158992061 @default.
- W2529200090 doi "https://doi.org/10.1016/j.intimp.2016.09.013" @default.
- W2529200090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27716592" @default.
- W2529200090 hasPublicationYear "2016" @default.
- W2529200090 type Work @default.
- W2529200090 sameAs 2529200090 @default.
- W2529200090 citedByCount "14" @default.
- W2529200090 countsByYear W25292000902018 @default.
- W2529200090 countsByYear W25292000902019 @default.
- W2529200090 countsByYear W25292000902020 @default.
- W2529200090 countsByYear W25292000902021 @default.
- W2529200090 countsByYear W25292000902022 @default.
- W2529200090 countsByYear W25292000902023 @default.
- W2529200090 crossrefType "journal-article" @default.
- W2529200090 hasAuthorship W2529200090A5008439349 @default.
- W2529200090 hasAuthorship W2529200090A5019072217 @default.
- W2529200090 hasAuthorship W2529200090A5047834392 @default.
- W2529200090 hasAuthorship W2529200090A5081701920 @default.
- W2529200090 hasConcept C108215921 @default.
- W2529200090 hasConcept C126322002 @default.
- W2529200090 hasConcept C150903083 @default.
- W2529200090 hasConcept C185592680 @default.
- W2529200090 hasConcept C207001950 @default.
- W2529200090 hasConcept C2775862500 @default.
- W2529200090 hasConcept C2778260677 @default.
- W2529200090 hasConcept C2779134260 @default.
- W2529200090 hasConcept C2779383735 @default.
- W2529200090 hasConcept C2780479503 @default.
- W2529200090 hasConcept C71924100 @default.
- W2529200090 hasConcept C86803240 @default.
- W2529200090 hasConcept C90924648 @default.
- W2529200090 hasConcept C98274493 @default.
- W2529200090 hasConceptScore W2529200090C108215921 @default.
- W2529200090 hasConceptScore W2529200090C126322002 @default.
- W2529200090 hasConceptScore W2529200090C150903083 @default.
- W2529200090 hasConceptScore W2529200090C185592680 @default.
- W2529200090 hasConceptScore W2529200090C207001950 @default.
- W2529200090 hasConceptScore W2529200090C2775862500 @default.
- W2529200090 hasConceptScore W2529200090C2778260677 @default.
- W2529200090 hasConceptScore W2529200090C2779134260 @default.
- W2529200090 hasConceptScore W2529200090C2779383735 @default.
- W2529200090 hasConceptScore W2529200090C2780479503 @default.
- W2529200090 hasConceptScore W2529200090C71924100 @default.
- W2529200090 hasConceptScore W2529200090C86803240 @default.
- W2529200090 hasConceptScore W2529200090C90924648 @default.
- W2529200090 hasConceptScore W2529200090C98274493 @default.
- W2529200090 hasLocation W25292000901 @default.
- W2529200090 hasLocation W25292000902 @default.
- W2529200090 hasOpenAccess W2529200090 @default.
- W2529200090 hasPrimaryLocation W25292000901 @default.
- W2529200090 hasRelatedWork W1975269797 @default.
- W2529200090 hasRelatedWork W2036344178 @default.
- W2529200090 hasRelatedWork W2037790316 @default.
- W2529200090 hasRelatedWork W2047798522 @default.
- W2529200090 hasRelatedWork W2083523365 @default.
- W2529200090 hasRelatedWork W2512544603 @default.
- W2529200090 hasRelatedWork W2907496294 @default.
- W2529200090 hasRelatedWork W3148381928 @default.
- W2529200090 hasRelatedWork W4200164771 @default.
- W2529200090 hasRelatedWork W2186812870 @default.
- W2529200090 hasVolume "40" @default.
- W2529200090 isParatext "false" @default.
- W2529200090 isRetracted "false" @default.
- W2529200090 magId "2529200090" @default.
- W2529200090 workType "article" @default.