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- W2529200093 abstract "The anterior hippocampus has been implicated in associative memory, and along with hippocampal volume, this type of memory declines with age. However, few cross-sectional studies include middle-aged samples, making it unclear at what point these age-related changes occur. In addition, although men and women have been shown to differ in associative memory and rates of age-related hippocampal atrophy, sex-differences in aging are rarely studied. To address these issues, we assessed memory for word-pairs, hippocampal volume and activation during encoding and retrieval, across middle-aged (n=39) and older (n=44) participants, specifically in relation to sex. Older adults showed significantly poorer associative memory compared to middle-aged adults, paralleled by smaller anterior hippocampi and less activation during successful retrieval. The age-by-sex interaction observed in memory performance was also mirrored in the volume and activation of the hippocampus, indicating more pronounced age-effects in men as compared to women. These results indicate a specific role of the anterior hippocampus in verbal associative memory and suggest they both decline between middle-age and older age." @default.
- W2529200093 created "2016-10-14" @default.
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- W2529200093 date "2017-01-01" @default.
- W2529200093 modified "2023-10-01" @default.
- W2529200093 title "Overlapping effects of age on associative memory and the anterior hippocampus from middle to older age" @default.
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- W2529200093 doi "https://doi.org/10.1016/j.bbr.2016.10.002" @default.
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