Matches in SemOpenAlex for { <https://semopenalex.org/work/W2529219523> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2529219523 endingPage "159" @default.
- W2529219523 startingPage "159" @default.
- W2529219523 abstract "Wrightia tinctoria Roxb. (R.Br.) is an Ayurvedic remedy, ethnomedically used in the treatment of various ailments. The present work was carried out to evaluate the anticancer and antioxidant activity as well as total phenolic and phytochemical contents of W. tinctoria bark methanolic extract (WTBM) by high-performance liquid chromatography (HPLC)-diode array detector. Antiproliferative activity of WTBM was evaluated against MDA-MB-231 and MCF-7 cancer cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation, and Hoechst staining. In addition, the antioxidant potential was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and 2,2- azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical cation decolorization assay. Total phenolic content was assessed by Folin-Ciocalteu method. The results demonstrated that WTBM exhibited significant antiproliferative effect against MDA-MB-231 (IC 50 = 88.9 ± 1.27 μg/ml) and MCF-7 (IC 50 = 45.71 ± 7.74 μg/ml) cancer cells in time- and dose-dependent manner. WTBM significantly suppresses colony formation and induces apoptosis in both MDA-MB-231 and MCF-7 cells as evident by morphological assessment, clonogenic assay, and Hoechst staining. The total phenolic content of WTBM was found to be 30.3 gallic acid equivalent mg/g dry weight of bark extract while IC 50 value for DPPH and ABTS radical scavenging activity was 72.2 ± 2.8 μg/ml and 45.16 ± 1.95 μg/ml, respectively. HPLC analysis showed the presence of gallic acid, rutin, and quercetin in WTBM. These findings demonstrated that WTBM significantly inhibited proliferation of breast cancer cells and induced apoptosis, suggesting the potential chemopreventive activity of W. tinctoria bark." @default.
- W2529219523 created "2016-10-14" @default.
- W2529219523 creator A5028147750 @default.
- W2529219523 creator A5036554710 @default.
- W2529219523 creator A5038420905 @default.
- W2529219523 creator A5046149999 @default.
- W2529219523 creator A5058690236 @default.
- W2529219523 creator A5080348997 @default.
- W2529219523 date "2016-01-01" @default.
- W2529219523 modified "2023-10-17" @default.
- W2529219523 title "Anticancer, antioxidant potential and profiling of polyphenolic compounds of Wrightia tinctoria Roxb. (R.Br.) bark" @default.
- W2529219523 cites W154375584 @default.
- W2529219523 cites W1936749636 @default.
- W2529219523 cites W1981989535 @default.
- W2529219523 cites W2090102281 @default.
- W2529219523 cites W2164572791 @default.
- W2529219523 cites W2212612964 @default.
- W2529219523 cites W2260835883 @default.
- W2529219523 cites W2263274623 @default.
- W2529219523 cites W2950662762 @default.
- W2529219523 doi "https://doi.org/10.4103/2231-4040.191428" @default.
- W2529219523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5052944" @default.
- W2529219523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27833897" @default.
- W2529219523 hasPublicationYear "2016" @default.
- W2529219523 type Work @default.
- W2529219523 sameAs 2529219523 @default.
- W2529219523 citedByCount "5" @default.
- W2529219523 countsByYear W25292195232020 @default.
- W2529219523 countsByYear W25292195232021 @default.
- W2529219523 countsByYear W25292195232023 @default.
- W2529219523 crossrefType "journal-article" @default.
- W2529219523 hasAuthorship W2529219523A5028147750 @default.
- W2529219523 hasAuthorship W2529219523A5036554710 @default.
- W2529219523 hasAuthorship W2529219523A5038420905 @default.
- W2529219523 hasAuthorship W2529219523A5046149999 @default.
- W2529219523 hasAuthorship W2529219523A5058690236 @default.
- W2529219523 hasAuthorship W2529219523A5080348997 @default.
- W2529219523 hasBestOaLocation W25292195231 @default.
- W2529219523 hasConcept C133446333 @default.
- W2529219523 hasConcept C179998833 @default.
- W2529219523 hasConcept C185592680 @default.
- W2529219523 hasConcept C18903297 @default.
- W2529219523 hasConcept C195475562 @default.
- W2529219523 hasConcept C2775963812 @default.
- W2529219523 hasConcept C2778004101 @default.
- W2529219523 hasConcept C2778362808 @default.
- W2529219523 hasConcept C2781031786 @default.
- W2529219523 hasConcept C2781263971 @default.
- W2529219523 hasConcept C2781401929 @default.
- W2529219523 hasConcept C31903555 @default.
- W2529219523 hasConcept C43617362 @default.
- W2529219523 hasConcept C55493867 @default.
- W2529219523 hasConcept C556039675 @default.
- W2529219523 hasConcept C70899900 @default.
- W2529219523 hasConcept C71924100 @default.
- W2529219523 hasConcept C86803240 @default.
- W2529219523 hasConceptScore W2529219523C133446333 @default.
- W2529219523 hasConceptScore W2529219523C179998833 @default.
- W2529219523 hasConceptScore W2529219523C185592680 @default.
- W2529219523 hasConceptScore W2529219523C18903297 @default.
- W2529219523 hasConceptScore W2529219523C195475562 @default.
- W2529219523 hasConceptScore W2529219523C2775963812 @default.
- W2529219523 hasConceptScore W2529219523C2778004101 @default.
- W2529219523 hasConceptScore W2529219523C2778362808 @default.
- W2529219523 hasConceptScore W2529219523C2781031786 @default.
- W2529219523 hasConceptScore W2529219523C2781263971 @default.
- W2529219523 hasConceptScore W2529219523C2781401929 @default.
- W2529219523 hasConceptScore W2529219523C31903555 @default.
- W2529219523 hasConceptScore W2529219523C43617362 @default.
- W2529219523 hasConceptScore W2529219523C55493867 @default.
- W2529219523 hasConceptScore W2529219523C556039675 @default.
- W2529219523 hasConceptScore W2529219523C70899900 @default.
- W2529219523 hasConceptScore W2529219523C71924100 @default.
- W2529219523 hasConceptScore W2529219523C86803240 @default.
- W2529219523 hasIssue "4" @default.
- W2529219523 hasLocation W25292195231 @default.
- W2529219523 hasLocation W25292195232 @default.
- W2529219523 hasLocation W25292195233 @default.
- W2529219523 hasLocation W25292195234 @default.
- W2529219523 hasOpenAccess W2529219523 @default.
- W2529219523 hasPrimaryLocation W25292195231 @default.
- W2529219523 hasRelatedWork W1978875935 @default.
- W2529219523 hasRelatedWork W2010360934 @default.
- W2529219523 hasRelatedWork W2011550240 @default.
- W2529219523 hasRelatedWork W2094481754 @default.
- W2529219523 hasRelatedWork W2129197564 @default.
- W2529219523 hasRelatedWork W2357518933 @default.
- W2529219523 hasRelatedWork W2946605659 @default.
- W2529219523 hasRelatedWork W3009495056 @default.
- W2529219523 hasRelatedWork W3146707841 @default.
- W2529219523 hasRelatedWork W2183560424 @default.
- W2529219523 hasVolume "7" @default.
- W2529219523 isParatext "false" @default.
- W2529219523 isRetracted "false" @default.
- W2529219523 magId "2529219523" @default.
- W2529219523 workType "article" @default.