FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2529262765> ?p ?o ?g. }

• W2529262765 abstract "The association of non-hereditary (sporadic) gastrointestinal stromal tumors (GISTs) and second primary malignancies is known to be nonrandom, although the underlying molecular mechanisms remain unknown. In this study, 136 of 749 (18.1%) patients with sporadic GISTs were found to have additional associated cancers, with gastrointestinal and genitourinary/gynecologic/breast cancers being the most prevalent. Gene mutations in GISTs and their associated colorectal cancers (CRCs) (n=9) were analyzed using a panel of 409 cancer-related genes, while a separate group of 40 sporadic CRCs not associated with GISTs served as controls. All 9 of the GISTs had either KIT (8 of 9) or PDGFRA (1 of 9) mutations that were not present in their associated CRCs. Conversely, all but one of the 9 GIST-associated CRCs exhibited an APC mutation, a TP53 mutation or both, while none of their corresponding GISTs harbored either APC or TP53 mutations. The genetic profile of CRCs with and without associated GISTs did not differ. Although population-based studies and case series worldwide, including ours, have unanimously indicated that the GIST-CRC association is nonrandom, our targeted ultra-deep sequencing unveiled a lack of driver-gene mutations linking sporadic GISTs to highly prevalent second primaries. Further studies are needed to elucidate other genetic alterations that may be responsible for this puzzling contradiction." @default.
• W2529262765 created "2016-10-14" @default.
• W2529262765 creator A5001390997 @default.
• W2529262765 creator A5004983925 @default.
• W2529262765 creator A5024024448 @default.
• W2529262765 creator A5036432442 @default.
• W2529262765 creator A5043854641 @default.
• W2529262765 creator A5048293343 @default.
• W2529262765 creator A5053209984 @default.
• W2529262765 creator A5054236046 @default.
• W2529262765 creator A5065544044 @default.
• W2529262765 creator A5090971578 @default.
• W2529262765 date "2016-10-28" @default.
• W2529262765 modified "2023-10-16" @default.
• W2529262765 title "Targeted ultra-deep sequencing unveils a lack of driver-gene mutations linking non-hereditary gastrointestinal stromal tumors and highly prevalent second primary malignancies: random or nonrandom, that is the question" @default.
• W2529262765 cites W114670017 @default.
• W2529262765 cites W1602615727 @default.
• W2529262765 cites W1984685395 @default.
• W2529262765 cites W1993182825 @default.
• W2529262765 cites W2001258296 @default.
• W2529262765 cites W2029857102 @default.
• W2529262765 cites W2048926228 @default.
• W2529262765 cites W2057470956 @default.
• W2529262765 cites W2058374622 @default.
• W2529262765 cites W2059336038 @default.
• W2529262765 cites W2067089521 @default.
• W2529262765 cites W2067428197 @default.
• W2529262765 cites W2077522154 @default.
• W2529262765 cites W2079978727 @default.
• W2529262765 cites W2081011458 @default.
• W2529262765 cites W2088704565 @default.
• W2529262765 cites W2091723114 @default.
• W2529262765 cites W2124581351 @default.
• W2529262765 cites W2151598596 @default.
• W2529262765 cites W2153748294 @default.
• W2529262765 cites W2154900997 @default.
• W2529262765 cites W2180435523 @default.
• W2529262765 cites W2318876506 @default.
• W2529262765 doi "https://doi.org/10.18632/oncotarget.12452" @default.
• W2529262765 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5347768" @default.
• W2529262765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27806309" @default.
• W2529262765 hasPublicationYear "2016" @default.
• W2529262765 type Work @default.
• W2529262765 sameAs 2529262765 @default.
• W2529262765 citedByCount "6" @default.
• W2529262765 countsByYear W25292627652017 @default.
• W2529262765 countsByYear W25292627652019 @default.
• W2529262765 countsByYear W25292627652020 @default.
• W2529262765 countsByYear W25292627652021 @default.
• W2529262765 countsByYear W25292627652023 @default.
• W2529262765 crossrefType "journal-article" @default.
• W2529262765 hasAuthorship W2529262765A5001390997 @default.
• W2529262765 hasAuthorship W2529262765A5004983925 @default.
• W2529262765 hasAuthorship W2529262765A5024024448 @default.
• W2529262765 hasAuthorship W2529262765A5036432442 @default.
• W2529262765 hasAuthorship W2529262765A5043854641 @default.
• W2529262765 hasAuthorship W2529262765A5048293343 @default.
• W2529262765 hasAuthorship W2529262765A5053209984 @default.
• W2529262765 hasAuthorship W2529262765A5054236046 @default.
• W2529262765 hasAuthorship W2529262765A5065544044 @default.
• W2529262765 hasAuthorship W2529262765A5090971578 @default.
• W2529262765 hasBestOaLocation W25292627651 @default.
• W2529262765 hasConcept C121608353 @default.
• W2529262765 hasConcept C126322002 @default.
• W2529262765 hasConcept C143998085 @default.
• W2529262765 hasConcept C526805850 @default.
• W2529262765 hasConcept C530470458 @default.
• W2529262765 hasConcept C71924100 @default.
• W2529262765 hasConceptScore W2529262765C121608353 @default.
• W2529262765 hasConceptScore W2529262765C126322002 @default.
• W2529262765 hasConceptScore W2529262765C143998085 @default.
• W2529262765 hasConceptScore W2529262765C526805850 @default.
• W2529262765 hasConceptScore W2529262765C530470458 @default.
• W2529262765 hasConceptScore W2529262765C71924100 @default.
• W2529262765 hasLocation W25292627651 @default.
• W2529262765 hasLocation W25292627652 @default.
• W2529262765 hasLocation W25292627653 @default.
• W2529262765 hasOpenAccess W2529262765 @default.
• W2529262765 hasPrimaryLocation W25292627651 @default.
• W2529262765 hasRelatedWork W1259741199 @default.
• W2529262765 hasRelatedWork W1500511523 @default.
• W2529262765 hasRelatedWork W1556973870 @default.
• W2529262765 hasRelatedWork W2053949450 @default.
• W2529262765 hasRelatedWork W2097172826 @default.
• W2529262765 hasRelatedWork W2370194643 @default.
• W2529262765 hasRelatedWork W2377859227 @default.
• W2529262765 hasRelatedWork W2520542459 @default.
• W2529262765 hasRelatedWork W2529545177 @default.
• W2529262765 hasRelatedWork W2565306534 @default.
• W2529262765 hasRelatedWork W2570295985 @default.
• W2529262765 hasRelatedWork W2588774966 @default.
• W2529262765 hasRelatedWork W2589802083 @default.
• W2529262765 hasRelatedWork W2591088975 @default.
• W2529262765 hasRelatedWork W2626451762 @default.
• W2529262765 hasRelatedWork W2783208510 @default.
• W2529262765 hasRelatedWork W2790666163 @default.
• W2529262765 hasRelatedWork W2884995047 @default.
• W2529262765 hasRelatedWork W2950636932 @default.
• W2529262765 hasRelatedWork W2954426661 @default.
• W2529262765 isParatext "false" @default.

• next