FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2529348414> ?p ?o ?g. }

• W2529348414 abstract "Many animal embryos use nuclear β-catenin (nβ-catenin) during the segregation of endomesoderm (or endoderm) from ectoderm. This mechanism is thus likely to be evolutionarily ancient. In the ascidian embryo, nβ-catenin reiteratively drives binary fate decisions between ectoderm and endomesoderm at the 16-cell stage, and then between endoderm and margin (mesoderm and caudal neural) at the 32-cell stage. At the 16-cell stage, nβ-catenin activates endomesoderm genes in the vegetal hemisphere. At the same time, nβ-catenin suppresses the DNA-binding activity of a maternal transcription factor Gata.a through a physical interaction, and Gata.a thereby activates its target genes only in the ectodermal lineage. In the present study, we found that this antagonism between nβ-catenin and Gata.a also operates during the binary fate switch at the 32-cell stage. Namely, in marginal cells where nβ-catenin is absent, Gata.a directly activates its target, Zic-r.b (ZicL), to specify the marginal cell lineages. Thus, the antagonistic action between nβ-catenin and Gata.a is consecutively involved during the segregation of the germ layers in ascidian embryos." @default.
• W2529348414 created "2016-10-14" @default.
• W2529348414 creator A5025601757 @default.
• W2529348414 creator A5041742217 @default.
• W2529348414 creator A5066535527 @default.
• W2529348414 creator A5082497882 @default.
• W2529348414 creator A5083700622 @default.
• W2529348414 date "2016-01-01" @default.
• W2529348414 modified "2023-10-13" @default.
• W2529348414 title "Antagonism between β-catenin and Gata.a sequentially segregates the germ layers of ascidian embryos" @default.
• W2529348414 cites W1486920424 @default.
• W2529348414 cites W1876881048 @default.
• W2529348414 cites W1900576709 @default.
• W2529348414 cites W1965675804 @default.
• W2529348414 cites W1976397093 @default.
• W2529348414 cites W1978732075 @default.
• W2529348414 cites W1986909055 @default.
• W2529348414 cites W1987377638 @default.
• W2529348414 cites W1990773683 @default.
• W2529348414 cites W1999745876 @default.
• W2529348414 cites W2016413669 @default.
• W2529348414 cites W2029609524 @default.
• W2529348414 cites W2051528260 @default.
• W2529348414 cites W2056063705 @default.
• W2529348414 cites W2057599463 @default.
• W2529348414 cites W2061668856 @default.
• W2529348414 cites W2064382304 @default.
• W2529348414 cites W2095869247 @default.
• W2529348414 cites W2102988868 @default.
• W2529348414 cites W2112047378 @default.
• W2529348414 cites W2117799366 @default.
• W2529348414 cites W2120347846 @default.
• W2529348414 cites W2134175977 @default.
• W2529348414 cites W2138602562 @default.
• W2529348414 cites W2155649413 @default.
• W2529348414 cites W2155987935 @default.
• W2529348414 cites W2170258388 @default.
• W2529348414 cites W2181933303 @default.
• W2529348414 cites W2277277196 @default.
• W2529348414 cites W2295783176 @default.
• W2529348414 cites W2308616703 @default.
• W2529348414 cites W2346784459 @default.
• W2529348414 cites W2474837920 @default.
• W2529348414 doi "https://doi.org/10.1242/dev.141481" @default.
• W2529348414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27707797" @default.
• W2529348414 hasPublicationYear "2016" @default.
• W2529348414 type Work @default.
• W2529348414 sameAs 2529348414 @default.
• W2529348414 citedByCount "16" @default.
• W2529348414 countsByYear W25293484142018 @default.
• W2529348414 countsByYear W25293484142019 @default.
• W2529348414 countsByYear W25293484142020 @default.
• W2529348414 countsByYear W25293484142021 @default.
• W2529348414 crossrefType "journal-article" @default.
• W2529348414 hasAuthorship W2529348414A5025601757 @default.
• W2529348414 hasAuthorship W2529348414A5041742217 @default.
• W2529348414 hasAuthorship W2529348414A5066535527 @default.
• W2529348414 hasAuthorship W2529348414A5082497882 @default.
• W2529348414 hasAuthorship W2529348414A5083700622 @default.
• W2529348414 hasBestOaLocation W25293484141 @default.
• W2529348414 hasConcept C104317684 @default.
• W2529348414 hasConcept C107459253 @default.
• W2529348414 hasConcept C129536746 @default.
• W2529348414 hasConcept C145103041 @default.
• W2529348414 hasConcept C153911025 @default.
• W2529348414 hasConcept C163952510 @default.
• W2529348414 hasConcept C18155467 @default.
• W2529348414 hasConcept C194058213 @default.
• W2529348414 hasConcept C196843134 @default.
• W2529348414 hasConcept C2777164004 @default.
• W2529348414 hasConcept C2779329299 @default.
• W2529348414 hasConcept C2780915607 @default.
• W2529348414 hasConcept C54355233 @default.
• W2529348414 hasConcept C86339819 @default.
• W2529348414 hasConcept C86803240 @default.
• W2529348414 hasConcept C87073359 @default.
• W2529348414 hasConcept C95444343 @default.
• W2529348414 hasConceptScore W2529348414C104317684 @default.
• W2529348414 hasConceptScore W2529348414C107459253 @default.
• W2529348414 hasConceptScore W2529348414C129536746 @default.
• W2529348414 hasConceptScore W2529348414C145103041 @default.
• W2529348414 hasConceptScore W2529348414C153911025 @default.
• W2529348414 hasConceptScore W2529348414C163952510 @default.
• W2529348414 hasConceptScore W2529348414C18155467 @default.
• W2529348414 hasConceptScore W2529348414C194058213 @default.
• W2529348414 hasConceptScore W2529348414C196843134 @default.
• W2529348414 hasConceptScore W2529348414C2777164004 @default.
• W2529348414 hasConceptScore W2529348414C2779329299 @default.
• W2529348414 hasConceptScore W2529348414C2780915607 @default.
• W2529348414 hasConceptScore W2529348414C54355233 @default.
• W2529348414 hasConceptScore W2529348414C86339819 @default.
• W2529348414 hasConceptScore W2529348414C86803240 @default.
• W2529348414 hasConceptScore W2529348414C87073359 @default.
• W2529348414 hasConceptScore W2529348414C95444343 @default.
• W2529348414 hasFunder F4320320883 @default.
• W2529348414 hasFunder F4320322892 @default.
• W2529348414 hasFunder F4320334764 @default.
• W2529348414 hasFunder F4320338075 @default.
• W2529348414 hasLocation W25293484141 @default.
• W2529348414 hasLocation W25293484142 @default.

• next